A new combined chemotherapy and immunotherapy regimen has been shown to significantly prolong survival in patients with metastatic melanoma.  If widely implemented, which of the following changes in disease occurrence measures would you most expect?

The incidence of diabetes mellitus in a population with very little migration has remained stable over the past 40 years (55 cases per 1000 people per year).  At the same time, prevalence of the disease increased threefold over the same period.  Which of the following is the best explanation for the changes in diabetes occurrence measures in the population?

In a survey of 10,000 IV drug abusers in town A, 1,000 turn out to be infected with hepatitis C and 500 infected with hepatitis B.  During two years of follow-up, 200 patients with hepatitis C infection and 100 patients with hepatitis B infection die.  Also during follow-up, 200 IV drug abusers acquire hepatitis C and 50 acquire hepatitis B.  Which of the following is the best estimate of the annual incidence of hepatitis C infection in IV drug abusers in town A?

The following graph represents the vaccination rate dynamics for hepatitis B in IV drug abusers in town A.

Which of the following hepatitis D statistics is most likely to be affected by the reported data?

In a city having a population of 1,000,000 there are 300,000 women of childbearing age.  The following statistics are reported for the city in the year 2000:

Fetal deaths: 200
Live births: 5,000
Maternal deaths: 70

Which of the following is the best estimate of the maternal mortality rate in the city in the year 2000?