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Question 1 of 3
1. Question
Question 1 of 3
A randomized double-blind clinical trial is conducted to evaluate the effect of a new hypolipidemic drug on the survival of patients after PTCA. 1000 patients undergoing PTCA are randomly assigned to the drug or placebo (500 patients in each group) and then followed for 3 years for the development of acute coronary syndrome. Severe acute myositis is reported as a rare side effect of the drug therapy, but the difference between the two groups in the occurrence of this side effect is not statistically significant (p = 0.09). The same side effect was reported in several small clinical trials of this drug. The failure to detect a statistically significant difference in the occurrence of acute myositis between the treatment and placebo groups is most likely due to:
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Question 2 of 3
2. Question
Question 2 of 3
The researchers want to further investigate the association between the new hypolipidemic drug and the occurrence of severe acute myositis. They note that several other studies have reported this side effect, but none of these studies demonstrated a statistically significant difference in rates of severe acute myositis between the treatment and placebo groups. The best method to further investigate a possible association between the drug and development of severe acute myositis is to:
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Question 3 of 3
3. Question
Question 3 of 3
A large prospective study is designed to assess the association between postmenopausal hormone replacement therapy (HRT) and the risk of dementia, Alzheimer type. Small studies conducted earlier suggest a possible protective effect of HRT. What is the probability that the study will show an association if in fact HRT does affect the risk of dementia?
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