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Question 1 of 5
1. Question
Question 1 of 5
An investigator suspects that acetaminophen use during the first trimester of pregnancy can cause neural tube defects. He estimates the general population risk of having neural tube defect is 1:1,000. Which of following is the best study design to investigate the hypothesis?
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Question 2 of 5
2. Question
Question 2 of 5
A group of investigators are studying the relationship between a particular 5-lipoxygenase genotype and atherosclerosis. A study population is randomly selected. Blood samples are obtained for leukocyte genotyping, and ultrasonography is performed to assess carotid intima-media thickness, a marker of atherosclerosis. It is then concluded that the particular 5-lipoxygenase genotype is associated with a predisposition to atherosclerosis. Which of the following choices identifies the study design used by the investigators?
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Question 3 of 5
3. Question
Question 3 of 5
Officials at a large community hospital report an increased incidence of acute lymphocytic leukemia (ALL) among children aged 5-12. They point out that some households in the community are exposed to chemical waste from a nearby factory. They believe that chemical waste causes leukemia. If a study is designed to evaluate the hospital officials’ claim, which of the following subjects are most likely to comprise the control group?
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Question 4 of 5
4. Question
Question 4 of 5
500 women aged 40-54 who present for routine check-ups are asked about their meat consumption. 20% of the women turn out to be vegetarian. During the ensuing 5 years, 5 vegetarians and 43 non-vegetarians develop colorectal cancer. Which of the following best describes the study design?
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Question 5 of 5
5. Question
Question 5 of 5
A group of researchers wants to investigate an outbreak of acute diarrhea that occurred in a small coastal town. About 50 people developed severe hemorrhagic diarrhea and one fatal case was reported. The researchers believe that the outbreak is related to the seafood prepared at one of the coastal restaurant. Which of the following study designs is most appropriate to investigate the hypothesis?
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