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15- Microbiology 15 (3 Hours)

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   Content of this Session
  • Sarcoptes scabiei
  • Pediculus humanus/ Phthirus pubis
  • Nature of human viruses
  • Parvovirus (B19)
  • Human Papilloma Virus (HPV)
  • BK Virus
  • JC Virus
  • Adenovirus

 

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[h] Microbiology & Antimicrobials Flashcards

[i] Master this session in just 5 minutes.

[q] What is the most likely diagnosis?

25 years old patient presenting with intensely pruritic rash in the flexor surfaces of the wrist, lateral surfaces of the fingers, and the finger webs, The rash is often worse at night +  Skin examination usually shows excoriations with small, crusted, red papules scattered around the region + skin scrapings from excoriated lesions that show mites, ova, and feces under light microscopy?

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[q] First-line therapy of scabies includes topical ……….., which blocks mite neurotransmission by impairing voltage-gated sodium channels.

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[q] Most enveloped nucleocapsid viruses acquire lipid bilayer envelopes by budding through the plasma membrane of the host cell. However, …………. bud through and acquire the lipid bilayer envelope from the host cell nuclear membrane.

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[q] Ether -induced disruption or dissolution of the viral envelope lipid results in …….?

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[q] DNA viruses Contain double-stranded DNA except ………?

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[q]  are naked viruses except ………………?

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[q] DNA viruses are linear except …………?

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[q] DNA viruses have icosahedral capsids except ………?

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[q] DNA viruses replicate in the nucleus except ……….?

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[q] Parvovirus B19 is attach to human erythroid cells via …..?

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[q]  is associated with erythema infectiosum (“fifth disease”), aplastic crises in those with sickle cell anemia, and hydrops fetalis (particularly when infection occurs before the 20th week of gestation).

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[q] What is the most likely diagnosis?

10 years old child presenting with  prodrome of low-grade fever, headache, malaise, and upper respiratory symptoms followed by the sudden appearance of an erythematous malar rash with circumoral pallor 2-5 days later, this rash has a “slapped-cheek” appearance,  As the facial rash fades, an erythematous rash in a reticular, lacelike pattern often appears on the trunk and extremities?

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[q] Aplastic crisis in sickle cell patients is usually secondary to ……….. infection of erythroid precursor cells in the bone marrow.

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[q] ………. causes hydrops fetalis if transmitted from mother to fetus (pregnant woman with with arthralgia with or without rash —> hydrops fetalis or spontaneous abortion).

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[q] ……….. infects basal cell layer of the stratified squamous epithelium and mucous membranes —-> Hyperkeratosis leads to the formation of the “wart”.

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[q] Serotypes …………… is responsible for this skin lesion?

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[q] Human papillomavirus (HPV) types 16 and 18 are strongly associated with …………….?

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[q] Integration of HPV DNA leads to high expression of ……….. leading to inactivation of the two suppressor genes p53 and retinoblastoma —> induction of abnormal mitosis.

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[q] koilocytic changes (perinuclear cytoplasmic vacuolization and nuclear enlargement) of squamous epithelium in pap smear is characteristic for infection with ………?

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[q] Site of latency of BK virus is ……….?

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[q] Site of latency of JC virus is ……….?

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[q] What is the most likely diagnosis?

HIV Patient with CD4 count less than 200 presenting with slowly progressive confusion, ataxia, and motor deficits + slowly progressive confusion, ataxia, and motor deficits?

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[q] What is the most likely diagnosis?

5 children from day care center presenting with acute onset of fever, pharyngitis, cough, nasal congestion, conjunctivitis, and enlarged cervical nodes?

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[q] What is the most likely diagnosis?

5 children from day care center presenting with urinary tract infection characterized by dysuria and hematuria?

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