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[h] Hematology & Oncology System Flashcards

[i] Master this session in just 5 minutes.

[q] What is the most likely diagnosis?

34 years old male patient who was admitted yesterday to perform cholecystectomy presenting with anxiety, insomnia, tremors, palpitation and diaphoresis with intact orientation. His daughter told you he is alcohol addict although he denied that when you asked him the day of admission?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1pbGQgQWxjb2hvbCB3aXRoZHJhd2FsIHN5bXB0b21zLg==

Cg==

Cg==[Qq]

[q] Alcoholic hallucinosis and withdrawal seizures are types of alcohol withdrawal syndrome that typically develops within 12-48 hours of the last drink and resolves within 24-48 hours. Unlike ……….., sensorium is intact and vital signs are usually stable.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGRlbGlyaXVtIHRyZW1lbnMu

Cg==

Jm5ic3A7

Cg==

[Qq]

[q] ………….. are the treatment of choice for patients with alcohol withdrawal.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJlbnpvZGlhemVwaW5lcy4=[Qq]

[q] ……….. is used for treatment of opioid intoxication.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IElWIG5hbG94b25lLg==[Qq]

[q] ………. should be suspected in patients with muscle and joint aches, abdominal cramping, nausea, diarrhea, rhinorrhea, and pupillary dilation.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEhlcm9pbiB3aXRoZHJhd2FsLg==[Qq]

[q] ……….. or ……. are used for treatment of opioid withdrawal.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IG1ldGhhZG9uZSBvciBidXByZW5vcnBoaW5lLg==[Qq]

[q] ………. is a drug of choice for maintenance treatment of opioid abuse. It is a potent, long-acting opioid agonist with good bioavailability and can be given in once- daily oral dosing. Its prolonged effects suppress withdrawal symptoms and cravings, allowing for more productive patient functioning.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1ldGhhZG9uZS4=[Qq]

[q] ………. is Long-acting opioid antagonist used for relapse prevention once detoxified.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE5hbHRyZXhvbmUu[Qq]

[q] ………….. is caused by infant withdrawal to opiates and usually presents in the first few days of life. It is characterized by irritability, a high-pitched cry, poor sleeping, tremors, seizures, sweating, sneezing, tachypnea, poor feeding, vomiting, and diarrhea.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE5lb25hdGFsIGFic3RpbmVuY2Ugc3luZHJvbWUu[Qq]

[q] When vital signs derangements or respiratory depression are seen with Benzodiazepines intoxication, ………. should be suspected.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGNvLWluZ2VzdGlvbiB3aXRoIG90aGVyIHNlZGF0aXZlLWh5cG5vdGljcy4=[Qq]

[q] Flumazenil is a receptor antagonist for …….?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJlbnpvZGlhemVwaW5lcy4=[Qq]

[q] What is the most likely diagnosis?

16 years old male patient presenting with symptoms of CNS depression that lasts for 15-45 minutes with perioral rash.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEluaGFsYW50IGFidXNlLg==[Qq]

[q] ……… have amphetamine properties that can cause severe agitation, combativeness, delirium, and psychosis. In contrast to

amphetamine, which have a much shorter duration of effect, it take several days or weeks to subside.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJhdGggc2FsdHMu[Qq]

[q] ………. should be suspected in an individual with weight loss, behavioral changes, and erythema of the turbinates and nasal septum.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENvY2FpbmUgYWJ1c2Uu[Qq]

[q] ………… intoxication cause Violence, impulsivity, psychomotor agitation, horizontal and vertical nystagmus, tachycardia, hypertension, analgesia, psychosis, delirium, seizures. Fatalities are often associated not with direct  intoxication but with related trauma due to combative behavior.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBoZW5jeWNsaWRpbmUgKFBDUCku[Qq]

[q] Phencyclidine (PCP) and lysergic acid diethylamide (LSD) intoxication present similarly, but agitation, aggression, and nystagmus occur more often in patients using ………. Visual hallucinations and depersonalization are hallmarks of ……….?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBoZW5jeWNsaWRpbmUgKFBDUCksIEx5c2VyZ2ljIGFjaWQgZGlldGh5bGFtaWRlIChMU0QgdXNlKS4=[Qq]

[q] The commonly used over-the- counter cough suppressant dextromethorphan may cause a false-positive result for …… in Standard urine drug screens (UDS).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IHBoZW5jeWNsaWRpbmUgKFBDUCku[Qq]

[q] ………. intoxication cause Euphoria, anxiety, paranoid delusions, perception of slowed time, impaired judgment, social withdrawal, ↑ appetite, dry mouth, conjunctival injection, tachycardia, hallucinations.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1hcmlqdWFuYSAoY2FubmFiaW5vaWQpLg==[Qq]

[q] …………. is a synthetic amphetamine with hallucinogenic properties.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1ETUEgKDMsNC1tZXRoeWxlbmVkaW94eS1tZXRoYW1waGV0YW1pbmUpLg==[Qq]

[q] Trifluoperazine, Fluphenazine, Haloperidol (Try to Fly High) are examples of …………?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEhpZ2ggcG90ZW5jeSBmaXJzdC1nZW5lcmF0aW9uIGFudGlwc3ljaG90aWNzLg==

Cg==

Cg==[Qq]

[q] Chlorpromazine, Thioridazine (Cheating Thieves are low) are examples of ………..?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IExvdyBwb3RlbmN5IGZpcnN0LWdlbmVyYXRpb24gYW50aXBzeWNob3RpY3Mu

Cg==

Jm5ic3A7

Cg==

[Qq]

[q] Neurologic side effects (extrapyramidal symptoms [EPS]) and drug-induced parkinsonism are more common with which type of  antipsychotics?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEhpZ2ggcG90ZW5jeSBmaXJzdC1nZW5lcmF0aW9uIGFudGlwc3ljaG90aWNzLg==

Cg==

Jm5ic3A7

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[q] Non-neurologic side effects (anticholinergic, antihistamine, and α1-blockade effects) are more common with which type of  antipsychotics?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IExvdyBwb3RlbmN5IGZpcnN0LWdlbmVyYXRpb24gYW50aXBzeWNob3RpY3Mu

Cg==

Jm5ic3A7

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[Qq]

[q] Endocrinal and metabolic side effects (Hyperprolactinemia, Obesity, Dyslipidemia, elevated blood glucose level) are more common with which type of  antipsychotics?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEF0eXBpY2FsIGFudGlwc3ljaG90aWNzIChzZWNvbmQtZ2VuZXJhdGlvbiBhbnRpcHN5Y2hvdGljcyku[Qq]

[q] Strong dopaminergic blockade causes an excess of cholinergic activity, resulting in extrapyramidal side effects (acute dystonic reactions, akathisia, parkinsonism). Medications with Muscarinic receptor antagonist properties, such as ………. or the antihistamine …………., help re-establish the dopaminergic-cholinergic balance and effectively treat acute dystonia.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJlbnp0cm9waW5lLCBkaXBoZW5oeWRyYW1pbmUu[Qq]

[q] ………….. is characterized by abnormal involuntary movements of the mouth, tongue, trunk, and extremities. It develops in the setting of prolonged exposure to dopamine-blocking agents, which is thought to result in the upregulation and supersensitivity of dopamine receptors.  When discontinuing the antipsychotic is not feasible, switching to clozapine is preferred.

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[f]IFRhcmRpdmUgZHlza2luZXNpYS4=

Cg==

Cg==[Qq]

[q] What is the most likely diagnosis?

42 years old patient presenting with fever, confusion, muscle rigidity, diaphoresis, tachycardia, hypertension, and elevated creatine kinase after taking haloperidol for 2 weeks?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE5ldXJvbGVwdGljIG1hbGlnbmFudCBzeW5kcm9tZS4=

Cg==

VHJlYXRtZW50IGluY2x1ZGVzIGRpc2NvbnRpbnVhdGlvbiBvZiBhbGwgYW50aXBzeWNob3RpY3MsIHN1cHBvcnRpdmUgaW50ZW5zaXZlIGNhcmUgKGFnZ3Jlc3NpdmUgY29vbGluZywgYW50aXB5cmV0aWNzLCBmbHVpZCBhbmQgZWxlY3Ryb2x5dGUgcmVwbGV0aW9uKSwgYW5kIHBvc3NpYmxlIHVzZSBvZiBkYW50cm9sZW5lIChhIHNrZWxldGFsIG11c2NsZSByZWxheGFudCkgb3IgZG9wYW1pbmVyZ2ljIGFnZW50cyAoQnJvbW9jcmlwdGluZSku

Cg==

Jm5ic3A7

[Qq]

[q] Aripiprazole, asenapine, clozapine, iloperidone, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone are examples of ……………..?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNlY29uZC1nZW5lcmF0aW9uIGFudGlwc3ljaG90aWNzLg==[Qq]

[q] ……….. is unique in that it has shown superiority in treatment-resistant schizophrenia and schizophrenia associated with persistent suicidality.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENsb3phcGluZS4=[Qq]

[q] Olanzapine → ………… as a side effect.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

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Cg==[Qq]

[q] …………. cause agranulocytosis (monitor WBC weekly) and seizures (dose related).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENsb3phcGluZS4gTXVzdCB3YXRjaCBib25lIG1hcnJvdyBjbG96ZWx5IHdpdGggY2xvemFwaW5lLg==

Cg==

Cg==[Qq]

[q] Antipsychotic medications exert their antipsychotic effects through dopamine antagonism. The blocking of dopamine results in hyperprolactinemia, which can lead to galactorrhea, amenorrhea, and infertility. ……… is most likely to increase prolactin.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFJpc3Blcmlkb25lLg==

Cg==

Cg==[Qq]

[q] Due to the risk of agranulocytosis, ………. is reserved for patients who have failed at least 2 antipsychotic trials.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENsb3phcGluZS4=[Qq]

[q] In cases of repeated antipsychotics medication nonadherence, switching to a ……… could be considered.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGxvbmctYWN0aW5nIGluamVjdGFibGUgYW50aXBzeWNob3RpYy4=[Qq]

[q] Patients with a single episode of major depressive disorder should continue antidepressants for ……. following acute response to reduce the risk of relapse. Patients with recurrent, chronic, or severe episodes should be considered for maintenance treatment (1-3 years or indefinitely).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGFuIGFkZGl0aW9uYWwgNiBtb250aHMu[Qq]

[q] Fluoxetine, paroxetine, sertraline, citalopram are examples of ………?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNlbGVjdGl2ZSBzZXJvdG9uaW4gcmV1cHRha2UgaW5oaWJpdG9ycyAoU1NSSXMpLiBGbGFzaGJhY2tzIHBhcmFseXplIHNlbmlvciBjaXRpemVucy4=[Qq]

[q] …………. normally takes 4–8 weeks for antidepressants to have an effect. It may cause SIADH, sexual dysfunction (anorgasmia, ↓ libido) as side effects.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNlbGVjdGl2ZSBzZXJvdG9uaW4gcmV1cHRha2UgaW5oaWJpdG9ycyAoU1NSSXMpLg==[Qq]

[q] Venlafaxine, desvenlafaxine, duloxetine, levomilnacipran, milnacipran are examples of ……?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNlcm90b25pbi1ub3JlcGluZXBocmluZSByZXVwdGFrZSBpbmhpYml0b3JzIChTTlJJcyku[Qq]

[q] What is the most likely diagnosis?

43 years old male patient taking Fluoxetine for treatment of major depressive disorder for 3 months and sumatriptan for headache recently presenting with hyperthermia, diaphoresis, clonus, hyperreflexia, hypertonia, tremor, seizure, Agitation and diarrhea?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNlcm90b25pbiBzeW5kcm9tZS4=

Cg==

UGhhcm1hY29sb2dpYyB0aGVyYXB5IGZvciBzZXZlcmUgY2FzZXMgaW52b2x2ZXMgdHJlYXRtZW50IHdpdGggc2Vyb3RvbmluIHJlY2VwdG9yIGFudGFnb25pc3RzIHN1Y2ggYXMgY3lwcm9oZXB0YWRpbmUgd2hpY2ggaXMgYSBmaXJzdC1nZW5lcmF0aW9uIGhpc3RhbWluZSBhbnRhZ29uaXN0IHdpdGggbm9uc3BlY2lmaWMgc2Vyb3RvbmluIHJlY2VwdG9yIGFudGFnb25pc3RpYyBwcm9wZXJ0aWVzLg==

Cg==

[Qq]

[q] Amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, doxepin, amoxapine are examples of ……?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFRyaWN5Y2xpYyBhbnRpZGVwcmVzc2FudHMgKFRDQXMpLg==[Qq]

[q] ………… inhibit fast sodium channel conduction, resulting in arrhythmias – the most common cause of death in patients with antidepressant intoxication.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFRyaWN5Y2xpYyBhbnRpZGVwcmVzc2FudHMuIFRyaS1D4oCZczogQ29udnVsc2lvbnMsIENvbWEsIENhcmRpb3RveGljaXR5Lg==

Cg==

Cg==

Rmx1aWQgcmVzdXNjaXRhdGlvbiB3aXRoIG5vcm1hbCBzYWxpbmUgYW5kIGh5cGVydG9uaWMgc29kaXVtIGJpY2FyYm9uYXRlIGFkbWluaXN0cmF0aW9uIGFyZSBjcnVjaWFsIGluIHRoZXNlIHBhdGllbnRzLg==[Qq]

[q] Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline are examples of ………?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1vbm9hbWluZSBveGlkYXNlIGluaGliaXRvcnMgKE1PQUlzKS4=[Qq]

[q] The acute onset of headache following a meal of aged cheeses in a patient treated with phenelzine raises concern for …………?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGh5cGVydGVuc2l2ZSBjcmlzaXMu[Qq]

[q] ……….. is an antidepressant with mild stimulant properties that can be particularly helpful for depressed patients with low energy, impaired concentration and hypersomnia.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJ1cHJvcGlvbi4=[Qq]

[q] ……. has a favorable side effect profile (no weight gain or sexual side effects) and activating effects, making it a good choice for patients with weight gain or SSRI-related sexual side effects. Also used for smoking cessation. It is associated with an increased seizure risk at high doses and contraindicated in patients with seizure disorders, anorexia, and bulimia nervosa.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJ1cHJvcGlvbi4=[Qq]

[q] ………. is used primarily for insomnia and cause priapism as a side effect.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFRyYXpvZG9uZS7CoENhbGxlZCB0cmFaWlpvYm9uZSBkdWUgdG8gc2VkYXRpdmUgYW5kIG1hbGUtc3BlY2lmaWMgc2lkZSBlZmZlY3RzLg==[Qq]

[q] ……….. is a mood stabilizer that causes Tremor, hypothyroidism, polyuria (causes nephrogenic diabetes insipidus), hyperparathyroidism with hypercalcemia, teratogenesis (Ebstein anomaly) as side effects.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IExpdGhpdW0u

Cg==

Cg==[Qq]

[q] A mild rash may develop in up to 10% of those treated with …………… whereas life-threatening Stevens-Johnson syndrome or toxic epidermal necrolysis may occur in 0.1%. Any occurrence of rash during the treatment of lamotrigine requires immediate discontinuation of the drug.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGxhbW90cmlnaW5lLg==

Cg==

Cg==[Qq]

[q] The anticonvulsant mood stabilizer …………. can cause elevated aminotransferases and in rare cases hepatic failure, most commonly in the first 6 months of treatment.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IHZhbHByb2F0ZS4=

Cg==

Cg==[Qq]

[q] ………… is a non-amphetamine stimulant that has become the first line agent in treatment of Narcolepsy because it is effective, well tolerated, and drug abuse is rare.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1vZGFmaW5pbC4=[Qq]

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