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[h] Biochemistry Flashcards

[i] Master this session in just 5 minutes.

[q] Cyanide is a deadly poison because it binds irreversibly to ……….. preventing electron transfer to oxygen.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGZlcnJpYyBpcm9uIG9mIGN5dG9jaHJvbWUgYS9hMyAoY29tcGxleCBJViku

[q] ………. may be used as an antidote for cyanide poisoning if given rapidly. They convert hemoglobin to methemoglobin, which binds cyanide in the blood before reaching the tissues.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE5pdHJpdGVzLg==

Jm5ic3A7

[Qq]

[q] Cyanide toxicity can be treated with an antidote such as …………, which directly binds cyanide molecules generating relatively nontoxic metabolites that are easily excreted in the urine.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGh5ZHJveG9jb2JhbGFtaW4gb3Igc29kaXVtIHRoaW9zdWxmYXRlLg==

Jm5ic3A7

[Qq]

[q] ………… directly inhibit mitochondrial ATP synthase —-> No ATP is produced because electron transport stops with an ↑ proton gradient.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9saWdvbXljaW4u

[q] ……….. ↑ permeability of membrane, causing a ↓ proton gradient and ↑ O2 consumption. ATP synthesis stops, but electron transport continues. Because the rate of the ETC increases, with no ATP synthesis, energy is released as heat.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IDIsNC1kaW5pdHJvcGhlbm9sICgyLDQtRE5QKS4=

[q] ………….. is a mitochondrial enzyme requiring biotin. It is activated by acetyl-CoA (from β-oxidation).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFB5cnV2YXRlIGNhcmJveHlsYXNlLg==

[q] ………… converts OAA to phosphoenolpyruvate (PEP) in a reaction that requires GTP.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBob3NwaG9lbm9scHlydXZhdGUgY2FyYm94eWtpbmFzZSAoUEVQQ0spLg==

Jm5ic3A7

[Qq]

[q] ………. in fed state causes ↑ PFK-2, ↓ 2,6- bisphosphosphatase activity leading to increased fructose 2,6-bisphosphate levels —> activate glycolysis and inhibit gluconeogenesis.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEluc3VsaW4u

[q] ……… in fasting state causes ↑ 2,6- bisphosphosphatase activity & ↓ PFK-2, leading to decreased fructose 2,6-bisphosphate levels and augmented gluconeogenesis.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEdsdWNhZ29uLg==

[q] The absence of ………….. in skeletal muscle accounts for the fact that muscle glycogen cannot serve as a source of blood glucose.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGdsdWNvc2UtIDYtcGhvc3BoYXRhc2Uu[Qq]

[q] Gluconeogenesis requires expenditure of ATP that is provided by …………?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IM6yLW94aWRhdGlvbiBvZiBmYXR0eSBhY2lkcy4=[Qq]

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