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14- Biochemistry 14 (2 Hours & 9 minutes)

[vdo id=’636acedc8c0e4af0864fa95d5a1d2cfc’]

 

   Content of this Session
  • Glycogen metabolism
  • Glycogenesis
  • Glycogenolysis
  • Glycogen storage diseases
  • Hexose monophosphate shunt
  • Glucose-6-phosphate dehydrogenase deficiency
  • ATP production
  • Universal electron acceptors

 

 

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[h] Biochemistry Flashcards

[i] Master this session in just 5 minutes.

[q] Glycogenolysis begins with ……….. shortening the glycogen chain by cleaving the alpha-1,4- glycosidic linkages between glucose residues through simple phosphorylation.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGdseWNvZ2VuIHBob3NwaG9yeWxhc2Uu[Qq]

[q] Increased intracellular calcium is a more powerful activator of ……….. Release of sarcoplasmic calcium stores following neuromuscular acetylcholine stimulation allows for synchronization of skeletal muscle contraction and glycogen breakdown, providing the energy necessary for anaerobic muscle contraction.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IG11c2NsZSBQaG9zcGhvcnlsYXNlIGtpbmFzZSAoUEspLg==

Cg==

Cg==[Qq]

[q] What is the most likely diagnosis?

5 years old child presenting with profound fasting hypoglycemia, lactic acidosis,  hepatomegaly, Hyperlipidemia, and Hyperuricemia?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFZvbiBHaWVya2UgZGlzZWFzZSAodHlwZSBJKSBkdWUgdG8gZGVmaWNpZW5jeSBvZiBHbHVjb3NlLTYtcGhvc3BoYXRhc2Uu[Qq]

[q] What is the most likely diagnosis?

1 years old child presenting with marked cardiomegaly, severe generalized hypotonia, exercise intolerance, macroglossia, and hepatomegaly with normal Blood glucose level?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBvbXBlIGRpc2Vhc2UgKHR5cGUgSUkpIGR1ZSBkZWZpY2llbmN5IG9mIGx5c29zb21hbCBlbnp5bWUgYWxwaGEgMSw0LWdsdWNvc2lkYXNlIChhY2lkIG1hbHRhc2UpLg==[Qq]

[q] What is the most likely diagnosis?

3 years old child presenting with mild hypoglycemia, hypertriglyceridemia, ketoacidosis, and hepatomegaly with accumulation of abnormally short outer dextrin-like structures in the cytosol of hepatocytes?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENvcmkgZGlzZWFzZSAodHlwZSBJSUkpIGR1ZSB0byBkZWZpY2llbmN5IG9mIERlYnJhbmNoaW5nIGVuenltZS4=[Qq]

[q] What is the most likely diagnosis?

3 years old child presenting with poor exercise tolerance, painful Muscle cramps, Myoglobinuria (red urine) with strenuous exercise, and arrhythmia from electrolyte abnormalities with normal liver and normal blood glucose level?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1jQXJkbGUgZGlzZWFzZSAodHlwZSBWKSBkdWUgdG8gZGVmaWNpZW5jeSBvZiBTa2VsZXRhbCBtdXNjbGUgZ2x5Y29nZW4gcGhvc3Bob3J5bGFzZSAoTXlvcGhvc3Bob3J5bGFzZSku[Qq]

[q] The oxidative portion of HMP shunt is catalyzed by …………, the rate limiting enzyme of the HMP shunt.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGdsdWNvc2UgNi1waG9zcGhhdGUgZGVoeWRyb2dlbmFzZS4=

Cg==

Cg==[Qq]

[q] The primary enzymes involved in the non-oxidative steps of the HMP shunt is transketolase.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IHRyYW5za2V0b2xhc2Uu

Cg==

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Cg==

[Qq]

[q] What is the most likely diagnosis?

9 years old African American male presenting with episodic symptoms of hemolytic anemia especially after infections or taking drugs, jaundice + Heinz bodies and bite cells?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEdsdWNvc2UtNi1waG9zcGhhdGUgZGVoeWRyb2dlbmFzZSBkZWZpY2llbmN5Lg==

Cg==

Cg==[Qq]

[q] Aerobic metabolism of one glucose molecule produces ….. net ATP via malate-aspartate shuttle (heart and liver), ….. net ATP via glycerol-3-phosphate shuttle (muscle).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IDMyLCAzMC4=[Qq]

[x][restart]

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