[qwiz style=”width: auto !important; min-height: auto !important; border-width: 4px !important; border-color: #0099cc !important; ” align=”center”]

[h] General Pathology Flashcards

[i] Master this session in just 5 minutes.

[q] ……….. is characterized by loss of uniformity in cell size and shape (pleomorphism); loss of tissue orientation; nuclear
changes (↑ nuclear:cytoplasmic ratio); often reversible.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IER5c3BsYXNpYS4=[Qq]

[q] …………. is irreversible severe dysplasia that involves the entire thickness of epithelium but does not penetrate the intact basement membrane.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENhcmNpbm9tYSBpbiBzaXR1Lg==[Qq]

[q] …………  generally has more prognostic value than grading.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFN0YWdpbmcu[Qq]

[q] ……… on T cells outcompetes CD28 for B7 on APCs —> loss of T cell costimulatory signal. Inhibited by ipilimumab.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENUTEEtNC4=

[q] The highest cancer incidence in males after skin cancer is ……….?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFByb3N0YXRlLg==[Qq]

[q] The highest cancer incidence in females after skin cancer is ……….?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJyZWFzdC4=[Qq]

[q] The highest cancer mortality in males and females is ………?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEx1bmcgY2FuY2VyLg==[Qq]

[q] Most sarcomas spread ………; most carcinomas spread via ………?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGhlbWF0b2dlbm91c2x5LCBseW1waGF0aWNzLg==[Qq]

[q] There are four carcinomas route hematogenously: …………, …………, ……….. and ………..?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGZvbGxpY3VsYXIgdGh5cm9pZCBjYXJjaW5vbWEsIGNob3Jpb2NhcmNpbm9tYSwgcmVuYWwgY2VsbCBjYXJjaW5vbWEsIGFuZCBoZXBhdG9jZWxsdWxhciBjYXJjaW5vbWEu[Qq]

[q] Gain of function mutation converts proto-oncogene (normal gene) to oncogene —-> increase cancer risk. Requires damage to (one or two) allele of a proto-oncogene.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IG9ubHkgb25lLg==[Qq]

[q] Loss of function of tumor suppressor gene —> increase cancer risk; (one or two) allele of a tumor suppressor gene must be lost for expression of disease.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFR3byAoS251ZHNvbuKAmXMgMi1oaXQgaHlwb3RoZXNpcyku[Qq]

[q] ……… is ATP-dependent efflux pump also known as multidrug resistance protein 1 (MDR1). Used to pump out toxins, including chemotherapeutic agents (one mechanism of decrease responsiveness or resistance to chemotherapy over time).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFAtZ2x5Y29wcm90ZWluLg==[Qq]

[q] ……… are Laminated, concentric spherules with dystrophic calcification.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBzYW1tb21hIGJvZGllcy4=

UFNBTU1PTQ==[Qq]aS bodies are seen in:
ƒ Papillary carcinoma of thyroid
ƒ Somatostatinoma
ƒ Adrenals (calcifying fibrous pseudotumor)
ƒ Meningioma
ƒ Malignant Mesothelioma
ƒ Ovarian serous carcinoma
ƒ Prolactinoma (Milk)
ƒ Serous endometrial carcinoma

[q] Weight loss, muscle atrophy, and fatigue that occur in chronic disease (cancer, AIDS, heart failure, COPD) is  mediated by ……?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFRORi3OsSwgSUZOLc6zLCBJTC0xLCBhbmQgSUwtNi4=[Qq]

[x][restart]

[/qwiz]