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[h] General Pharmacology Flashcards

[i] Master this session in just 5 minutes.

[q] The ………. is the major involuntary portion of the nervous system and is responsible for automatic, unconscious bodily functions, such as control of heart rate and blood pressure and both gastrointestinal and genitourinary functions.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEF1dG9ub21pYyBOZXJ2b3VzIFN5c3RlbSAoQU5TKS4=[Qq]

[q] Sympathetic outflow is originated from …………, but parasympathetic outflow is originated from ………..?

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[f]IFRob3JhY29sdW1iYXIsIENyYW5pb3NhY3JhbC4=

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[q] An important anatomic difference between the SANS and PANS is that the ganglia of the SANS lie in ……… adjacent to the vertebral column, whereas most of the ganglia of the PANS system are located in ……….?

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[f]IHR3byBwYXJhdmVydGVicmFsIGNoYWlucywgbmVhciBvciB3aXRoaW4gdGhlIGVuZC1vcmdhbi4=

Cg==

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[Qq]

[q] Nicotinic receptors (N_N) are located on ………… and in ……..?

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[f]IGNlbGwgYm9kaWVzIGluIGdhbmdsaWEgb2YgYm90aCBQQU5TIGFuZCBTQU5TLCB0aGUgYWRyZW5hbCBtZWR1bGxhLg==

Cg==

Cg==[Qq]

[q] Nicotinic receptors (N_M) are located on ……..?

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[f]IHRoZSBza2VsZXRhbCBtdXNjbGUgbW90b3IgZW5kIHBsYXRlIGlubmVydmF0ZWQgYnkgc29tYXRpYyBtb3RvciBuZXJ2ZXMu

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Cg==[Qq]

[q] ……… is directly innervated by preganglionic sympathetic fibers without autonomic ganglia or postganglionic neuron.

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[f]IEFkcmVuYWwgbWVkdWxsYS4=[Qq]

[q] …….. are part of the sympathetic pathway but are innervated by cholinergic fibers (sympathetic nervous system

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFN3ZWF0IGdsYW5kcy4=[Qq]

[q] ………….. use Gs coupled receptors and activate adenyl cyclase as a second messenger, but ………. use Gi coupled receptors and inhibit adenyl cyclase as a second messenger.

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Cg==

Cg==[Qq]

[q] Choline uptake in presynaptic neuron is inhibited by ………..?

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[q] ……… inhibits vesicular acetylcholine transporter (VAT) preventing the storage of acetylcholine.

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[f]IFZlc2FtaWNvbC4=[Qq]

[q] ……… interacts with synaptobrevin and other proteins to prevent ACh release and is used in blepharospasm, strabismus/hyperhydrosis, dystonia, and cosmetics.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJvdHVsaW51bSB0b3hpbi4=[Qq]

[q] ………… is a direct Cholinomimetic drug on bowel and bladder and can be used in post-operative ileus and non obstructive urinary retention.

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[q] ………… is a direct Cholinomimetic drug on the eye and can be used to relieves intraocular pressure in open-angle glaucoma.

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[q] ………… is a direct Cholinomimetic drug on airway when
inhaled and can be used as a challenge test for diagnosis of asthma.

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Cg==[Qq]

[q] ………… is a direct Cholinomimetic drug on the eye and secretions and can be used for treatment of Open-angle and closed-angle glaucoma,
xerostomia (Sjögren syndrome)?

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[q] ………… is an indirect Cholinomimetic drug that can cross the blood-brain barrier and can be used as Antidote for anticholinergic toxicity (Atropine toxicity).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBoeXNvc3RpZ21pbmUuIFBoeXNvc3RpZ21pbmUg4oCccGh5eGVz4oCdIGF0cm9waW5lIG92ZXJkb3NlLg==

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Cg==[Qq]

[q] ………… and ……….. are indirect Cholinomimetic drug that can NOT cross the blood-brain barrier and can be used in treatment of Myasthenia gravis.

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[Qq]

[q] ………… is an indirect Cholinomimetic drug that was historically used to diagnose myasthenia gravis; replaced by anti-AChR Ab (anti-acetylcholine
receptor antibody) test.

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[q] ………… is an indirect Cholinomimetic drug that is 1st line for Alzheimer disease.

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Cg==

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[Qq]

[q] What is the most likely diagnosis?

60 years old farmer presenting with lethargy, excessive sweeting, pupil is constrictive but reactive to light, bradycardia, diarrhea and urine incontinence?

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[f]IE9yZ2Fub3Bob3NwaGF0ZXMgUG9pc29uaW5nLg==

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[q] How will you manage a case of Organophosphates Poisoning?

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[f]

Cg==

MS4gUmV2ZXJzZSBtdXNjYXJpbmljIGFuZCBDTlMgc2lkZSBlZmZlY3RzIGJ5IGF0cm9waW5lLCBjb21wZXRpdGl2ZSBpbmhpYml0b3IuIEF0cm9waW5lIGNhbiBjcm9zcyBCQkIgdG8gcmVsaWV2ZSBDTlMgc3ltcHRvbXMu

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[Qq]

2. Remove the contaminated clothes.

3. Nicotinic side effects can be reversed by pralidoxime, regenerates AChE via dephosphorylation if given early.

 

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