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[h] Hematology & Oncology System Flashcards

[i] Master this session in just 5 minutes.

[q] What is the most likely diagnosis?

8 years old male presenting with deep joint bleeding (hemarthrosis) in the right knee + Laboratory findings include: ↑ PTT; normal PT. ↓ FVIII. Normal platelet count and bleeding time.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEhlbW9waGlsaWEgQS4gR2VuZXRpYyBmYWN0b3IgVklJSSAoRlZJSUkpIGRlZmljaWVuY3kgZHVlIHRvIFgtbGlua2VkIHJlY2Vzc2l2ZSBtdXRhdGlvbiAocHJlZG9taW5hbnRseSBhZmZlY3RzIG1hbGVzKS4=[Qq]

[q] Hemophilia A and B are indistinguishable clinically, as both demonstrate similar symptoms, similar inheritance patterns, and isolated prolongation of the PTT except …….?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEZJWCBsZXZlbHMgYXJlIGRlY3JlYXNlZCBpbnN0ZWFkIG9mIEZWSUlJLg==

[q] The vitamin K-dependent coagulation factors (II, VII IX, X) are initially produced by the liver in an inactive form, and are then activated by vitamin K-dependent carboxylation. Defect in vitamin K-dependent coagulation factors may be due to clotting factors deficiency (liver dysfunction) or vitamin k deficiency. Thus, failure of a prolonged PT to correct with vitamin K supplementation indicates ……?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IGxpdmVyIGR5c2Z1bmN0aW9uLg==

[q] Why PT is the first to be prolonged in liver diseases that affect the synthetic function of the liver to produce the clotting factors?

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[f]IEJlY2F1c2UgRmFjdG9yIFZJSSwgcGFydCBvZiB0aGUgZXh0cmluc2ljIHBhdGh3YXksIGhhcyB0aGUgc2hvcnRlc3QgaGFsZi1saWZlLg==[Qq]

[q] Why vitamin K injection is given prophylactically to all newborns at birth?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFRvIHByZXZlbnQgaGVtb3JyaGFnaWMgZGlzZWFzZSBvZiB0aGUgbmV3Ym9ybi4gTmV3Ym9ybnMgbGFjayBHSSBjb2xvbml6YXRpb24gYnkgYmFjdGVyaWEgdGhhdCBub3JtYWxseSBzeW50aGVzaXplIHZpdGFtaW4gSyBhbmQgYnJlYXN0ZmVkIG1pbGsgaXMgcG9vciBpbiB2aXRhbWluIEsu[Qq]

[q] What is the most likely diagnosis?

13 years old male presenting with mild mucosal and skin bleeding and re-bleeding after surgical procedures (wisdom tooth extraction) + Laboratory findings include: ↑ bleeding time. ↑ PTT, normal PT. Decreased FVIII half-life + Abnormal ristocetin test + patient has a family history of similar condition?

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[f]IFZvbiB3aWxsYnJhbmQgZGlzZWFzZS4=[Qq]

[q] Factor VIII is synthesized by the liver and stored in endothelial cells. Desmopressin acetate (DDAVP) is a synthetic vasopressin analog that releases von Willebrand factor and factor VIII from the endothelium. It is used for the treatment of  ……?

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[f]IEhlbW9waGlsaWEgQSBhbmQgVm9uIHdpbGxicmFuZCBkaXNlYXNlLg==[Qq]

[q] What is the most likely diagnosis?

Patient admitted in ICU due to meningococcemia presenting with bleeding from IV puncture sites and body orifices + Laboratory findings include:↓ platelet count and prolonged bleeding time, ↑ PT/PTT, ↓ fibrinogen, Microangiopathic hemolytic anemia, Elevated fibrin split products, particularly D-dimer.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IERpc3NlbWluYXRlZCBpbnRyYXZhc2N1bGFyIGNvYWd1bGF0aW9uIChESUMpLg==

[q] What is the most likely diagnosis?

Patient presenting with diffuse skin necrosis after taking warfarin as anticoagulant for DVT?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFdhcmZhcmluIGluZHVjZWQgc2tpbiBuZWNyb3NpcyBkdWUgdG8gcHJvdGVpbiBDIGRlZmljaWVuY3ku[Qq]

[q] What is the most likely diagnosis?

25 years old Patient presenting with history of recurrent DVT and pulmonary embolism. Patient’s father died from Pulmonary Embolism in age of 40?

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[f]IEZhY3RvciBWIExlaWRlbi4gSXQgaXMgYSBtdXRhdGVkIGZvcm0gb2YgZmFjdG9yIFYgdGhhdCBsYWNrcyB0aGUgY2xlYXZhZ2Ugc2l0ZSBmb3IgZGVhY3RpdmF0aW9uIGJ5IHByb3RlaW5zIEMgYW5kIFMuIE1vc3QgY29tbW9uIGluaGVyaXRlZCBjYXVzZSBvZiBoeXBlcmNvYWd1bGFibGUgc3RhdGUu[Qq]

[q] What is the most likely diagnosis?

Patient presenting with hypercoagulable state and history of recurrent DVT + PTT does not rise with standard heparin dosing?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEluaGVyaXRlZCBBbnRpdGhyb21iaW4gZGVmaWNpZW5jeS4gQ2FuIGFsc28gYmUgYWNxdWlyZWQgKHJlbmFsIGZhaWx1cmUvbmVwaHJvdGljIHN5bmRyb21lKSDihpIgYW50aXRocm9tYmluIGxvc3MgaW4gdXJpbmUg4oaSIOKGkyBpbmhpYml0aW9uIG9mIGZhY3RvcnMgSUlhIGFuZCBYYS4=[Qq]

[q] What is the most likely diagnosis?

60 years old patient presenting with Weakness, fatigue, and dyspnea, Pale conjunctiva and skin, Spoon nails (koilonychia) + Laboratory findings include: Hb: 9.2 g/dL, MCV: 75  with ↑ red cell distribution width (RDW),  ↓ ferritin; ↑ TIBC, ↓ Serum iron; ↓ % saturation,↑ Free erythrocyte protoporphyrin (FEP) + Fecal occult blood test is positive.

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[f]IElyb24gZGVmaWNpZW5jeSBhbmVtaWEu

[q] …….. is a Triad of iron deficiency anemia, esophageal webs, and glossitis. Presenting with anemia, dysphagia, and beefy-red tongue.

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[f]IFBsdW1tZXItVmluc29uIHN5bmRyb21lLg==[Qq]

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