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[h] Hematology & Oncology System Flashcards

[i] Master this session in just 5 minutes.

[q] What is the most likely diagnosis?

65 years old male presenting with history of recurrent infection, generalized lymphadenopathy, neutrophils > 18000, peripheral smear shows smudge cells.

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[f]IENocm9uaWMgbHltcGhvY3l0aWMgbGV1a2VtaWEvU21hbGwgbHltcGhvY3l0aWMgbHltcGhvbWEu[Qq]

 

[q] …… is the the most common cause of death in CLL.

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[f]IEluZmVjdGlvbiBkdWUgdG8gSHlwb2dhbW1hZ2xvYmluZW1pYS4=[Qq]

[q] What is the most likely diagnosis?

55 years old male presenting with splenomegaly, Bone marrow aspirate shows dry tap and Cells are positive for tartrate-resistant acid phosphatase, B cells have filamentous, hair-like projections (fuzzy appearing on LM).

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[f]IEhhaXJ5IGNlbGwgbGV1a2VtaWEu[Qq]

[q] What is the most likely diagnosis?

55 years old male presenting with splenomegaly, high granulocyte counts especially basophils, cytologic analysis shows t(9;22).

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[f]IENocm9uaWMgbXllbG9pZCBsZXVrZW1pYSAoQ01MKS4gRHJpdmVuIGJ5IHQoOTsyMikgKFBoaWxhZGVscGhpYSBjaHJvbW9zb21lKSB3aGljaCBnZW5lcmF0ZXMgYSBCQ1ItQUJMIGZ1c2lvbiBwcm90ZWluIHdpdGggaW5jcmVhc2VkIHR5cm9zaW5lIGtpbmFzZSBhY3Rpdml0eS4=

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[q] Myeloproliferative disorders is associated with a mutation in ….., a non-receptor tyrosine kinase except CML  is associated with ……

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[f]IEphbnVzIGtpbmFzZSAyIChKQUsyKSwgUGhpbGFkZWxwaGlhIGNocm9tb3NvbWUu[Qq]

[q] What is the most likely diagnosis?

54 years old male presenting with facial flushing, Itching, especially after bathing, severe, burning pain and red-blue coloration of extremities, Blurry vision and headache + HB: 19 g/dl, Hematocrit: 59.

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[f]IFBvbHljeXRoZW1pYSBWZXJhLg==

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SW4gcG9seWN5dGhlbWlhIHZlcmEsIG11dGF0aW9ucyBpbiBKQUsyIGNhdXNlIGNvbnN0aXR1dGl2ZSBraW5hc2UgYWN0aXZhdGlvbiwgcmVuZGVyaW5nIGhlbWF0b3BvaWV0aWMgY2VsbHMgbW9yZSBzZW5zaXRpdmUgdG8gZ3Jvd3RoIGZhY3RvcnMgc3VjaCBhcyBlcnl0aHJvcG9pZXRpbiBhbmQgdGhyb21ib3BvaWV0aW4u[Qq]

[q] In PV, erythropoietin (EPO) levels are …. , and Sao2 is …..

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[q] In reactive polycythemia due to high altitude or lung disease, Sao2 is…., and EPO is ……

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[q] In reactive polycythemia due to ectopic EPO production from renal cell carcinoma, EPO is …., and Sao2 is …..

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[q] What is the most likely diagnosis?

40 years old patient presenting with recurrent infection, anemia, thrombocytopenia, splenomegaly, peripheral smear shows teardrop RBC’s, Bone marrow aspirate shows dry tap, + JAK2 Kinase mutation.

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[q] What is the most likely diagnosis?

45 years old female presenting with fever, chills, and night sweats, painless cervical lymphadenopathy + lymph node biopsy shows large B cells with binucleate or bilobed with the 2 halves as mirror images and prominent nucleoli; classically positive for CD15 and CD30, Lymph node is divided by bands of sclerosis; RS cells are present in lake-like spaces (lacunar cells)?

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[f]IEhvZGdraW4gbHltcGhvbWEgKE5vZHVsYXIgc2NsZXJvc2lzIHN1YnR5cGUpLg==[Qq]

[q] …… has the best prognosis of all types of Hodgkin lymphoma, but …..  is the most aggressive at all types; usually seen in the elderly and HIV-positive individuals.

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[f]IEx5bXBob2N5dGUtcmljaCwgTHltcGhvY3l0ZS1kZXBsZXRlZC4=[Qq]

[q] Benign lymph node enlargement in response to antigenic stimulation is associated with a …… proliferation of lymphocytes. But malignant lymph node enlargement is associated with a….. proliferation of lymphocytes.

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[f]IHBvbHljbG9uYWwsIG1vbm9jbG9uYWwu[Qq]

[q] What is the most likely diagnosis?

55 years old male presenting with generalized lymphadenopathy, low-grade fever, night sweats with indolent course + lymph node biopsy shows Disruption of normal lymph node architecture that form follicle-like nodules with Bcl2 overexpression in follicles + cytogenic analysis shows by t(14,18).

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[f]IEZvbGxpY3VsYXIgbHltcGhvbWEuIEJDTDIgb24gY2hyb21vc29tZSAxOCB0cmFuc2xvY2F0ZXMgdG8gdGhlIElnIGhlYXZ5IGNoYWluIGxvY3VzIG9uIGNocm9tb3NvbWUgMTQg4oaSIFJlc3VsdHMgaW4gb3ZlcmV4cHJlc3Npb24gb2YgQmNsMiwgd2hpY2ggaW5oaWJpdHMgYXBvcHRvc2lzICYjODIxMTsmZ3Q7IGZvbGxpY3VsYXIgbHltcGhvbWEu[Qq]

[q] What is the most likely diagnosis?

45 years old male presenting with generalized lymphadenopathy, low-grade fever, night sweats + lymph node biopsy shows Neoplastic proliferation of small B cells (CD20) that expands to the mantle zone + cytogenic analysis shows by t(11;14).

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[f]IE1hbnRsZSBjZWxsIGx5bXBob21hLg==

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[Qq]

Overexpression of cyclin D1 promotes G1/S transition in the cell cycle, facilitating neoplastic proliferation.

[q] What is the most likely diagnosis?

45 years old female presenting with long history of Hashimotos thyroiditis but she noticed sudden enlargement of the neck  +  Thyroid biopsy shows Neoplastic proliferation of small B cells (CD20) that expands to the marginal zone + cytogenic analysis shows by t(11;18).

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[f]IE1hcmdpbmFsIHpvbmUgbHltcGhvbWEu

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[q] What is the most likely diagnosis?

African American child presenting with jaw mass + Biopsy shows Neoplastic proliferation of intermediate-sized B cells (CD20+) with – Overexpression of c-myc,  high mitotic index and high cell death rate are typically seen. Benign macrophages that phagocytize the resulting cellular debris (“tingible body macrophages”) are diffusely distributed throughout the malignant tissue. The clear spaces that surround these macrophages create “starry sky” appearance?

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[Qq]

– Overexpression of c-myc oncogene promotes cell growth.

– Almost all cases of endemic Burkitt lymphoma are associated with Epstein-Barr virus (EBV) infection.

[q] What is the most likely diagnosis?

HIV positive patient with  CD4< 50  presenting with confusion, memory loss, seizures + MRI shows Solitary mass in his brain, Histology shows Neoplastic proliferation of B cells lymphocytes?

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[f]IFByaW1hcnkgY2VudHJhbCBuZXJ2b3VzIHN5c3RlbSBseW1waG9tYS4=[Qq]

[q] What is the most likely diagnosis?

45 years old Asian male presenting with generalized lymphadenopathy with hepatosplenomegaly, low-grade fever, night sweats, Skin rash, and lytic (punched-out) bone lesions with hypercalcemia + lymph node biopsy shows Neoplastic proliferation of mature CD4 T cells.

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[f]IEFkdWx0IFQtY2VsbCBsZXVrZW1pYS9seW1waG9tYS4=[Qq]

[q] What is the most likely diagnosis?

45 years old Asian male presenting with generalized lymphadenopathy with hepatosplenomegaly, low-grade fever, night sweats, Skin rash+ lymph node biopsy shows Neoplastic proliferation of mature CD4 T cells + Peripheral smear shows lymphocytes with cerebriform nuclei (Sezary cells).

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[q] t(8;14) is associated with ……?

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[q] t(11;14) is associated with ……?

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[q] t(11;18) is associated with ……?

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[q] t(15;17) is associated with ……?

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[q] t(9;22) (Philadelphia chromosome) is associated with ……?

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