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[h] Hematology & Oncology System Flashcards

[i] Master this session in just 5 minutes.

[q] ……. is a folic acid analog that competitively inhibits dihydrofolate reductase –> ↓ dTMP –> ↓ DNA synthesis.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1ldGhvdHJleGF0ZS4=

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[q] What is the chemotherapeutic drug that cause these side effects?

– Myelosuppression, which is reversible with leucovorin “rescue”.

– Toxic to 2L (Lung, Liver) → Pulmonary fibrosis, Hepatotoxicity.

– Mucositis (mouth ulcers).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE1ldGhvdHJleGF0ZS4=[Qq]

[q] Pyrimidine analog bioactivated to 5-FdUMP, which covalently complexes folic acid. This complex inhibits thymidylate synthase –> ↓ dTMP –> ↓ DNA synthesis.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEZsdW9yb3VyYWNpbC4=

Cg==

Cg==[Qq]

[q] What is the chemotherapeutic drug that cause these side effects?

Myelosuppression, worsened with the addition of leucovorin (folinic acid).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IDUtZmx1b3JvdXJhY2lsLg==[Qq]

[q] …… is a Purine (thiol) analogs —> ↓ de novo purine synthesis. Activated by HGPRT.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEF6YXRoaW9wcmluZSwgNi1tZXJjYXB0b3B1cmluZS4=

Cg==

Cg==[Qq]

[q] …….. is the drug of choice for hairy cell leukemia.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENsYWRyaWJpbmUu[Qq]

[q] …… is an alkylating agent that cause pulmonary fibrosis as a side effect.

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[f]IFB1bG1vbmFyeSBmaWJyb3Npcy4=

Cg==

Cg==[Qq]

[q] …… is an alkylating agent that cause hemorrhagic cystitis as a side effect that can prevented with …… or …….?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEN5Y2xvcGhvc3BoYW1pZGUsIHByZXZlbnRlZCB3aXRoIG1lc25hICh0aGlvbCBncm91cCBvZiBtZXNuYSBiaW5kcyB0b3hpYyBtZXRhYm9saXRlcykgb3IgTi1hY2V0eWxjeXN0ZWluZS4=

Cg==

Cg==[Qq]

[q] …… is an alkylating agent that can Cross blood-brain barrier –>  CNS + used in Brain tumors (including glioblastoma multiforme) + and cause CNS toxicity (convulsions, dizziness, ataxia) as a side effect?

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[f]IE5pdHJvc291cmVhcyAoQ2FybXVzdGluZSwgbG9tdXN0aW5lLCBzZW11c3RpbmUsIHN0cmVwdG96b2Npbiku[Qq]

[q] ……. is a chemotherapeutic drug that induces free radical formation —> breaks in DNA strands and cause pulmonary fibrosis as a side effect.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJsZW9teWNpbi4=

Cg==

Cg==[Qq]

[q] …….. is a chemotherapeutic drug that causes Cardiotoxicity (dilated cardiomyopathy) as a side effect.

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[f]IERveG9ydWJpY2luLg==

Cg==

Cg==[Qq]

[q] The most effective method of preventing doxorubicin cardiomyopathy is ……..?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IERleHJhem94YW5lLiBJdCBpcyBhbiBpcm9uLWNoZWxhdGluZyBhZ2VudCB0aGF0IGRlY3JlYXNlcyBmb3JtYXRpb24gb2Ygb3h5Z2VuIGZyZWUgcmFkaWNhbHMgYnkgZG94b3J1YmljaW4gYW5kIG90aGVyIGFudGhyYWN5Y2xpbmVzLg==[Qq]

[q] ……. is a microtubule inhibitors that bind β-tubulin and inhibit its polymerization into microtubules —> prevent mitotic spindle formation (M-phase arrest)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFZpbmNyaXN0aW5lLCB2aW5ibGFzdGluZS4=[Qq]

[q] …….. is a vinca alkaloid that causes neurotoxicity (areflexia, peripheral neuritis).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFZpbmNyaXN0aW5lLg==

Cg==

Cg==[Qq]

[q] ….. is a microtubule inhibitors that hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down (anaphase cannot occur).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBhY2xpdGF4ZWwu[Qq]

[q] …… is a platinum-containing compound that cause – Nephrotoxicity as a side effect that can prevented with …… and …….?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENpc3BsYXRpbi4gUHJldmVudCBuZXBocm90b3hpY2l0eSB3aXRoIGFtaWZvc3RpbmUgKGZyZWUgcmFkaWNhbCBzY2F2ZW5nZXIpIGFuZCBjaGxvcmlkZSAoc2FsaW5lKSBkaXVyZXNpcy4=

Cg==

Cg==[Qq]

[q] ……. is a chemotherapeutic drug that inhibits topoisomerase II.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEV0b3Bvc2lkZS4=[Qq]

[q] ……. is a chemotherapeutic drug that – Inhibits ribonucleotide reductase →↓ DNA Synthesis (S-phase specific) and (↑ HbF).

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEh5ZHJveHl1cmVhLg==[Qq]

[q] …… is a Monoclonal antibody against VEGF.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJlVmFjaXp1bWFiLiAoQmVWYWNpenVtYWIgaW5oaWJpdHMgQmxvb2QgVmVzc2VsKS4=[Qq]

[q] ……. is a monoclonal antibody against EGFR.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENldHV4aW1hYi4=[Qq]

[q] ……. is a EGFR tyrosine kinase inhibitor.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEVybG90aW5pYi4=[Qq]

[q] ……. is a tyrosine kinase inhibitor of BCR-ABL (Philadelphia chromosome fusion gene in CML) and c-kit (common in GI stromal tumors).

[c]IFNob3fCoCBtZS B0aGUgYW5zd2Vy[Qq]

[f]IEltYXRpbmliLg==[Qq]

[q]  …….. is a monoclonal antibody against CD20, which is found on most B-cell neoplasms.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFJpdHV4aW1hYi4=[Qq]

[q] ….. is a small molecule inhibitor of BRAF oncogene ⊕ melanoma.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFZlbXVyYWZlbmliLg==[Qq]

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