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[h] Microbiology & Antimicrobials Flashcards

[i] Master this session in just 5 minutes.

[q] What is the most likely diagnosis?

6th months old male child presenting with recurrent lower respiratory tract infections and Giardia lamblia infection + Absent B cells in peripheral blood with ↓ Ig of all classes + absent germinal centers in the lymph nodes?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFgtbGlua2VkIChCcnV0b24pIGFnYW1tYWdsb2J1bGluZW1pYS4=

Cg==

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JiM4MjExOyBEZWZlY3QgaW4gQlRLLCBhIHR5cm9zaW5lIGtpbmFzZSBnZW5lICYjODIxMjsmZ3Q7IG5vIEItY2VsbCBtYXR1cmF0aW9uLg==[Qq]

[q] What is the most likely diagnosis?

10 years old patient presenting with Recurrent otitis media, sinusitis, bronchitis, pneumonias and chronic malabsorption symptoms due to giardiasis + serum findings shows ↓ IgA with normal IgG, IgM levels?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNlbGVjdGl2ZSBJZ0EgZGVmaWNpZW5jeS4=

Cg==

Cg==

JiM4MjExOyBXaGVuIHRyYW5zZnVzZWQgd2l0aCBibG9vZCBvciBibG9vZCBwcm9kdWN0cyBjb250YWluaW5nIHNtYWxsIGFtb3VudHMgb2YgbGdBIHRoZXNlIHBhdGllbnRzIG1heSBkZXZlbG9wIHBvdGVudGlhbGx5IGZhdGFsIGFuYXBoeWxhY3RpYyByZWFjdGlvbnMuIEdhbW1hLWdsb2J1bGluIHByZXBhcmF0aW9ucyBzaG91bGQgbm90IGJlIHVzZWQgZm9yIHRyZWF0bWVudCBvZiB0aGVzZSBwYXRpZW50cyBhcyBpdCBtYXkgaW5jcmVhc2UgdGhlIHN5bnRoZXNpcyBvZiBhbnRpLWxnQSBhbnRpYm9kaWVzIGJlY2F1c2UgdGhlIHBhdGllbnQmIzgyMTc7cyBib2R5IHJlY29nbml6ZXMgaXQgYXMgYSBmb3JlaWduLg==[Qq]

[q] What is the most likely diagnosis?

25 years old female patient presenting with recurrent lower respiratory tract infections and Giardia lamblia infection + normal B cells in peripheral blood with ↓ Ig of all classes?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENvbW1vbiB2YXJpYWJsZSBpbW11bm9kZWZpY2llbmN5Lg==[Qq]

[q] What is the most likely diagnosis?

18 years old patient presenting with recurrent infections by viral, fungal, protozoan and intracellular bacterial pathogens + truncus arteriosus + cleft palate + serum findings shows: ↓ T cells, ↓PTH, ↓ Ca + CXR shows absent thymic shadow + poorly developed paracortex region in lymph nodes?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFRoeW1pYyBhcGxhc2lhIChEaUdlb3JnZSBzeW5kcm9tZSku

Cg==

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JiM4MjExOyAyMnExMSBtaWNyb2RlbGV0aW9uOyBtYWxkZXZlbG9wbWVudCBvZiB0aGUgdGhpcmQgYW5kIGZvdXJ0aCBwaGFyeW5nZWFsIHBvdWNoIGRlcml2YXRpdmVzIO+DoCBhYnNlbnQgdGh5bXVzIGFuZCBwYXJhdGh5cm9pZCBnbGFuZC4=[Qq]

[q] What is the most likely diagnosis?

22 years old patient presenting with Cold (noninflamed) staphylococcal Abscesses, retained Baby teeth, Coarse facies, eczema, and  bone Fractures from minor trauma + serum findings shows: ↑IgE, eosinophils?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEF1dG9zb21hbCBkb21pbmFudCBoeXBlci1JZ0Ugc3luZHJvbWUgKEpvYiBzeW5kcm9tZSku

Cg==

Cg==

JiM4MjExOyBEZWZpY2llbmN5IG9mIFRoMTcgY2VsbHMgZHVlIHRvIFNUQVQzIG11dGF0aW9uIOKGkiBpbXBhaXJlZCByZWNydWl0bWVudCBvZiBuZXV0cm9waGlscyB0byBzaXRlcyBvZiBpbmZlY3Rpb24u[Qq]

[q] Localized candidiasis is common in HIV-positive patients, while …….. are more likely to have systemic disease.

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[f]IG5ldXRyb3BlbmljIGluZGl2aWR1YWxzLg==[Qq]

[q] What is the most likely diagnosis?

2 years old child presenting with recurrent infections caused by bacteria, viruses, fungi, and opportunistic pathogens as well as failure to thrive, thrush and chronic diarrhea + Absence of thymic shadow (CXR) and germinal centers in lymph node biopsy and ↓ T-cell receptor excision circles (TRECs)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNldmVyZSBjb21iaW5lZCBpbW11bm9kZWZpY2llbmN5IChTQ0lEKS4=

Cg==

Cg==

JiM4MjExOyBTZXZlcmFsIHR5cGVzIGluY2x1ZGluZyBkZWZlY3RpdmUgSUwtMlIgZ2FtbWEgY2hhaW4gKG1vc3QgY29tbW9uLCBYLWxpbmtlZCku

[Qq]

– Adenosine deaminase deficiency is the second most cause of SCID. Retroviral gene therapy for this illness is promising. Retroviral vectors are used to “infect” patient hematopoietic stem cells with the genetic code for adenosine deaminase thereby resulting in production of this enzyme by all daughter cells of that stem cell.

[q] What is the most likely diagnosis?

6 years old child presenting with increased risk of sinopulmonary infections,  Cerebellar ataxia, and oculocutaneous telangiectasias + imaging of the brain shows cerebellar atrophy?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEF0YXhpYS10ZWxhbmdpZWN0YXNpYS4=

Cg==

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JiM4MjExOyBJdCBpcyBhbiBhdXRvc29tYWwgcmVjZXNzaXZlIGNvbmRpdGlvbiB0aGF0IG9jY3VycyBkdWUgdG8gbXV0YXRpb24gb2YgQVRNIGdlbmUuIEFUTSAoQXRheGlhIFRlbGFuZ2llY3Rhc2lhIE11dGF0ZWQpIGdlbmUgaXMgcmVzcG9uc2libGUgZm9yIEROQSBicmVhayByZXBhaXIu[Qq]

[q] What is the most likely diagnosis?

12 years old patient presenting with Severe pyogenic infections early in life; opportunistic infection with Pneumocystis, Cryptosporidium, CMV + serum findings shows ↑ IgM with ↓↓ IgG, IgA, IgE?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEh5cGVyLUlnTSBzeW5kcm9tZS4=

Cg==

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JiM4MjExOyBHZW5ldGljIGRlZmljaWVuY3kgaW4gdGhlIENELTQwIFQtbHltcGhvY3l0ZSBsaWdhbmQgdGhhdCBpcyBlc3NlbnRpYWwgaW4gaW5kdWNpbmcgQi1jZWxscyB0byBzd2l0Y2ggY2xhc3Nlcy4=[Qq]

[q] What is the most likely diagnosis?

2 years old male child presenting with recurrent (pyogenic) infections, eczema, thrombocytopenia + peripheral blood smear shows smaller than normal platelets?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFdpc2tvdHQtQWxkcmljaCBzeW5kcm9tZS4=

Cg==

Cg==

JiM4MjExOyBNdXRhdGlvbiBpbiBXQVMgZ2VuZSAoWC1saW5rZWQgcmVjZXNzaXZlKTsgbGV1a29jeXRlcyBhbmQgcGxhdGVsZXRzIHVuYWJsZSB0byByZW9yZ2FuaXplIGFjdGluIGN5dG9za2VsZXRvbiDihpIgZGVmZWN0aXZlIGFudGlnZW4gcHJlc2VudGF0aW9uLg==[Qq]

[q] What is the most likely diagnosis?

13 years old patient presenting with recurrent bacterial skin and mucosal infections, absent pus formation, impaired wound healing, CBC shows abnormally high numbers of neutrophils?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IExldWtvY3l0ZSBhZGhlc2lvbiBkZWZpY2llbmN5ICh0eXBlIDEpLg==[Qq]

[q] What is the most likely diagnosis?

20 years old patient presenting with recurrent pyogenic infections by staphylococci and streptococci, partial albinism, peripheral neuropathy, progressive neurodegeneration, infiltrative lymphohistiocytosis + peripheral blood smear shows Giant granules in granulocytes and platelets?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENow6lkaWFrLUhpZ2FzaGkgc3luZHJvbWUu

Cg==

Cg==

JiM4MjExOyBEZWZlY3QgaW4gbHlzb3NvbWFsIHRyYWZmaWNraW5nIHJlZ3VsYXRvciBnZW5lIChMWVNUKS4=

[Qq]

– Microtubule dysfunction in phagosome-lysosome fusion; autosomal recessive.

[q] What is the most likely diagnosis?

20 years old mal patient presenting with recurrent infection with catalase ⊕ organisms + Abnormal dihydrorhodamine test with ↓ green fluorescence + Nitroblue tetrazolium dye reduction test is ⊝ and patient’s neutrophils fail to turn blue upon nitroblue tetrazolium?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENocm9uaWMgZ3JhbnVsb21hdG91cyBkaXNlYXNlLg==[Qq]

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