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[h] Musculoskeletal System Flashcards

[i] Master this session in just 5 minutes.

[q] “What is the most likely diagnosis?”

34 years old male presenting with Pruritic, erythematous, oozing rash with crusted lesions and Intense pruritus in antecubital fossa with chronic course marked by exacerbations and remissions + skin biopsy shows epidermal accumulation of edematous fluid in the intercellular spaces (spongiosis)?

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[f]IEF0b3BpYyAoZWN6ZW1hdG91cykgZGVybWF0aXRpcy4=

[Qq]

[q] “What is the most likely diagnosis?”

34 years old male presenting with Pruritic, erythematous, oozing rash with crusted lesions in his hand after wearing his new nickel watch + skin biopsy shows epidermal accumulation of edematous fluid in the intercellular spaces (spongiosis)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENvbnRhY3QgZGVybWF0aXRpcy4=

[Qq]

[q] …… pathogenesis is related to chronic inflammation of hair follicles and associated sebaceous glands.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEFjbmUgdnVsZ2FyaXMu

JiM4MjExOyBIb3Jtb25lLWFzc29jaWF0ZWQgaW5jcmVhc2UgaW4gc2VidW0gcHJvZHVjdGlvbiAoc2ViYWNlb3VzIGdsYW5kcyBoYXZlIGFuZHJvZ2VuIHJlY2VwdG9ycykgYW5kIGV4Y2VzcyBrZXJhdGluIHByb2R1Y3Rpb24gYmxvY2sgZm9sbGljbGVzIOKGkiBmb3JtaW5nIGNvbWVkb25lcy4=

– Follicles clogged with sebum provide an anaerobic, lipid-rich environment for the proliferation of Propionibacterium acnes, an anaerobic diphtheroid that is part of normal skin flora.

– Propionibacterium acnes infection produces lipases that break down sebum, releasing proinflammatory fatty acids → results in pustule or nodule formation.

[q] A negative pregnancy test (urine or serum) is required prior to prescribing …… to a female with acne vulgaris?

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[f]IElzb3RyZXRpbm9pbiAoVml0YW1pbiBBIGRlcml2YXRpdmVzKS4=

Vml0YW1pbiBBIGRlcml2YXRpdmVzIGFyZSBjb250cmFpbmRpY2F0ZWQgaW4gcHJlZ25hbmN5LiBBIG5lZ2F0aXZlIHByZWduYW5jeSB0ZXN0ICh1cmluZSBvciBzZXJ1bSkgaXMgcmVxdWlyZWQgcHJpb3IgdG8gcHJlc2NyaWJpbmcsIGFuZCBhYnN0aW5lbmNlL2NvbnRyYWNlcHRpb24gaXMgcmVjb21tZW5kZWQuIFNleHVhbGx5IGFjdGl2ZSB3b21lbiBzaG91bGQgYmUgYWR2aXNlZCB0byB1c2UgMiBmb3JtcyBvZiBjb250cmFjZXB0aW9uIGFuZCB0YWtlIG1vbnRobHkgcHJlZ25hbmN5IHRlc3RzLg==

[Qq]

[q] “What is the most likely diagnosis?”

25 years old female presenting with facial erythematous papules and pustules, but no comedones, associated with facial flushing in response to external stimuli (alcohol, heat)?

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[f]IFJvc2FjZWEu

[Qq]

[q] “What is the most likely diagnosis?”

30 years old female presenting with Well-circumscribed, salmon-colored plaques covered with a loosely adherent, silvery scale?

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[f]IFBzb3JpYXNpcy4=

[Qq]

[q] ……… and …… are important association of psoriasis with increased risk in human leukocyte antigen B27-positive?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBzb3JpYXNpcyBpcyBhc3NvY2lhdGVkIHdpdGggbmFpbCBwaXR0aW5nIChZZWxsb3ctYnJvd24gZGlzY29sb3JhdGlvbiwgcGl0dGluZywgdGhpY2tlbmluZywgb3IgY3J1bWJsaW5nKSBhbmQgcHNvcmlhdGljIGFydGhyaXRpcw==LiBUaGUgcmlzayBpcyBpbmNyZWFzZWQgaW4gcGF0aWVudHMgd2hvIGFyZSBodW1hbiBsZXVrb2N5dGUgYW50aWdlbiBCMjctcG9zaXRpdmUu

[q] Histologic changes associated with psoriasis are ………?

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[f]IEhpc3RvbG9neSBzaG93czo=
CiYjODIxMTsgQWNhbnRob3NpcyAoZXBpZGVybWFsIGh5cGVycGxhc2lhKS4=

[Qq]– Hyperkeratosis (↑ thickness of stratum corneum).

– Parakeratosis (retention of keratinocyte nuclei in the stratum corneum).

– ↑ Stratum spinosum and corneum↓ stratum granulosum (reduced or absent stratum granulosum).

– Collections of neutrophils in the stratum corneum (Munro microabscesses).

– Elongation of the dermal papillae with thinning of the epidermis above elongated dermal papillae, a finding responsible for the pinpoint bleeding evident when the scale is removed from the plaque (Auspitz sign).

[q] First-line treatment options for localized psoriasis include …….. and ………..?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IHRvcGljYWwgY29ydGljb3N0ZXJvaWRzIChkaWZsb3Jhc29uZSksIHZpdGFtaW4gRCBhbmFsb2dzIChjYWxjaXBvdHJpZW5lLCBjYWxjaXRyaW9sKS4=[Qq]

[q] “What is the most likely diagnosis?”

40 years old male with history of hepatitis C presenting with Pruritic, Purple, Polygonal Planar Papules and Plaques + Histology shows Sawtooth infiltrate of lymphocytes at dermal-epidermal junction and hypergranulosis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IExpY2hlbiBwbGFudXMu[Qq]

[q] “What is the most likely diagnosis?”

25 years old male presenting with painful flaccid bullae and erosions affecting the skin and mucosal membranes, – Thin-walled bullae rupture easily upon manual stroking of skin, leading to shallow erosions with dried crust, The bullae spread laterally when pressure is applied on top + histology shows: Acantholysis (separation) of stratum spinosum keratinocytes (normally connected by desmosomes) results in suprabasal blisters. Basal layer cells remain attached to basement membrane via hemidesmosomes (tombstone’ appearance) + Immunofluorescence highlights IgG surrounding keratinocytes in a “fish net pattern”?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBlbXBoaWd1cyB2YWxnYXJpcy4gQXV0b2ltbXVuZSBidWxsb3VzIGRpc2Vhc2UgY2hhcmFjdGVyaXplZCBieSBhdXRvYW50aWJvZGllcyBkaXJlY3RlZCBhZ2FpbnN0IGRlc21vZ2xlaW4gKGNvbXBvbmVudCBvZiBkZXNtb3NvbWVzLCB3aGljaCBjb25uZWN0IGtlcmF0aW5vY3l0ZXMgaW4gdGhlIHN0cmF0dW0gc3Bpbm9zdW0pLg==

[q] “What is the most likely diagnosis?”

25 years old male presenting with Tense bullae of the skin do not rupture easily (oral mucosa is spared) + ⊝ Nikolsky sign + – Immunofluorescence highlights IgG along basement membrane (linear pattern)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEJ1bGxvdXMgcGVtcGhpZ29pZC4gQnVsbG91cyBwZW1waGlnb2lkIGlzIGNoYXJhY3Rlcml6ZWQgYnkgYXV0b2FudGlib2RpZXMgKElnRykgdG8gdGhlIGhlbWlkZXNtb3NvbWVzIGFsb25nIHRoZSBiYXNlbWVudCBtZW1icmFuZSBvZiB0aGUgZGVybWFsLWVwaWRlcm1hbCBqdW5jdGlvbi4=

[q] “What is the most likely diagnosis?”

27 years old patient with history of celiac disease presenting with erythematous pruritic papules, vesicles, and bullae that appear bilaterally and symmetrically on the elbows + Histologicallythere is microabscesses containing fibrin and neutrophils at the dermal papillae tips.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IERlcm1hdGl0aXMgaGVycGF0aWZvcm1pcy4=[Qq]

[q] “What is the most likely diagnosis?”

22 years old male patient with history of HSV presenting with multiple types of lesions: macules, papules, vesicles, target lesions?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEVyeXRoZW1hIG11bHRpZm9ybWUuIFBhdGhvZ2VuLXNwZWNpZmljIGN5dG90b3hpYyBULWNlbGxzIHRoZW4gcmVjb2duaXplIGZvcmVpZ24gYW50aWdlbnMgcHJvZHVjZWQgYnkga2VyYXRpbm9jeXRlcyBhbmQgaW5pdGlhdGUgYW4gaW5mbGFtbWF0b3J5IGNhc2NhZGUgdGhhdCByZXN1bHRzIGluIGVwaXRoZWxpYWwgZGFtYWdlLg==[Qq]

[q] “What is the most likely diagnosis?”

Patient presenting with fever, bullae formation and necrosis, sloughing of skin at dermal-epidermal junction including the mucus membranes of the moth and eyes?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFN0ZXZlbnMtSm9obnNvbiBzeW5kcm9tZS4=[Qq]

[x][restart]

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