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[h] General Pharmacology Flashcards

[i] Master this session in just 5 minutes.

[q] Drug permeation and absorption is directly proportional to ……….., ………, and ………. and inversely proportional to ………?

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[f]IGxpcGlkIHNvbHViaWxpdHksIENvbmNlbnRyYXRpb24gZ3JhZGllbnQsIGFuZCBTdXJmYWNlIGFyZWEgYW5kIHZhc2N1bGFyaXR5LiBEcnVnIGlvbml6YXRpb24u[Qq]

[q] Many drugs are weak acids or weak bases and can exist in either nonionized or ionized forms in an equilibrium, depending on ……… and ……….?

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[f]IHRoZSBwSCBvZiB0aGUgZW52aXJvbm1lbnQgYW5kIHRoZSBwS2EgKHRoZSBwSCBhdCB3aGljaCB0aGUgbW9sZWN1bGUgaXMgNTAlIGlvbml6ZWQgYW5kIDUwJSBub25pb25pemVkKS4=[Qq]

[q] Only the ……… form of a drug crosses biomembranes.

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[f]IG5vbmlvbml6ZWQgKHVuY2hhcmdlZCku[Qq]

[q] The …….. form is better renally excreted because it is water soluble.

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[f]IGlvbml6ZWQu[Qq]

[q] If you want to increase the absorption of a drug or to decrease its clearance ——> put it in environment with …….., but if you want to increase its clearance –> put it in environment with …..?

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[f]IHRoZSBzYW1lIFBoLCB0aGUgb3Bwb3NpdGUgUGgu[Qq]

[q] ……… can be used to alkalinize the urine.

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[f]IE5hSENPMywgYWNldGF6b2xhbWlkZS4=[Qq]

[q] ……… can be used to acidify the urine.

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[f]IE5INENsLCB2aXRhbWluIEMsIGNyYW5iZXJyeSBqdWljZS4=[Qq]

[q] Passive diffusion and Facilitated Diffusion transport occurs (down or against) concentration gradient, while active transport occurs (down or against) concentration gradient.

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[f]IGRvd24sIGFnYWluc3Qu[Qq]

[q] ……… and ……. are types of transport that need carriers, so they are saturable.

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[f]IEZhY2lsaXRhdGVkIERpZmZ1c2lvbiBhbmQgQWN0aXZlIHRyYW5zcG9ydC4=[Qq]

[q] ……….. does not involve absorption, and there is no loss of drug (Bioavailability = 100%).

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[f]IEludHJhdmFzY3VsYXIgYWRtaW5pc3RyYXRpb24gKElWKS4=[Qq]

[q] …….. is used to measure of the fraction of a dose that reaches the systemic circulation.

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[f]IEJpb2F2YWlsYWJpbGl0eSAoZiku[Qq]

[q] ………. can be calculated by measuring area under the curve of the dug after taken orally divided by area under the curve of the same drug after taken intravenously.

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[f]IEJpb2F2YWlsYWJpbGl0eSAoZiku

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[q] Oral bioavailability is dependent on ……… and ………?

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[f]IHRoZSBhYnNvcnB0aXZlIHByb3BlcnRpZXMgb2YgdGhlIGRydWcgYXMgd2VsbCBhcyBpdHMgZmlyc3QtcGFzcyBtZXRhYm9saXNtLg==[Qq]

[q] Why the bioavailability of drugs that are taken suppository are better than the drugs taken orally?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFRoZSBhbW91bnQgb2YgZHJ1ZyBleHBvc2VkIHRvIHRoZSBsaXZlciB3aXRoaW4gdGhlIHBvcnRhbCBibG9vZCBmbG93IGlzIHRoZSBtYWpvciBkZXRlcm1pbmFudCBvZiBoZXBhdGljIG9yIGZpcnN0LXBhc3MgbWV0YWJvbGlzbS4=

Cg==

74KnIFRoZSBzdXBlcmlvciByZWN0YWwgdmVpbnMgZHJhaW4gdG8gdGhlIHBvcnRhbCBjaXJjdWxhdGlvbiB2aWEgdGhlIGluZmVyaW9yIG1lc2VudGVyaWMgdmVpbi4=
Cu+CpyBUaGUgbWlkZGxlIGFuZCBpbmZlcmlvciByZWN0YWwgdmVpbnMsIGhvd2V2ZXIsIGRyYWluIHRvIHRoZSBzeXN0ZW1pYyBjaXJjdWxhdGlvbiB2aWEgdGhlIGludGVybmFsIGlsaWFjIGFuZCBpbnRlcm5hbCBwdWRlbmRhbCB2ZWlucywgcmVzcGVjdGl2ZWx5Lg==

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[Qq]

[q] When Vd of the drug is 3 liters, this means this drug is sequestered in (tissues or blood)?

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[f]IEJsb29kLg==[Qq]

[q] Characteristics of a drug such as high molecular weight, high plasma protein binding, high charge, and hydrophilicity tend to trap the drug in the (tissues or blood) compartment resulting in a (low or high) Vd.

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[f]IGJsb29kLCBsb3cu[Qq]

[q] When Vd of the drug is 103 liters, this means this drug is sequestered in (tissues or blood)?

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[f]IHRpc3N1ZXMu[Qq]

[q] What is the most likely diagnosis?

56 years old patient presenting with hemiplegia although he was on warfarin as a prophylaxes of PE, his Ct shows intracranial hemorrhage, after revising his previous history you discovered he was on quinolones the previous 2 weeks for treatment of pneumonia?

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[f]IEhlbW9ycmhhZ2ljIHN0cm9rZSBkdWUgdG8gd2FyZmFyaW4gdG94aWNpdHkgYmVjYXVzZSBxdWlub2xvbmVzIGFyZSBDWVA0NTAgaW5oaWJpdG9yLg==

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[q] Drugs that may cause Drug-induced SLE by slow acetylators are …….., ………., and ……….?

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[f]IGh5ZHJhbGF6aW5lLCBwcm9jYWluYW1pZGUsIGlzb25pYXppZCAoSU5IKS4=[Qq]

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