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[h] Hematology & Oncology System Flashcards

[i] Master this session in just 5 minutes.

[q] What is the most likely diagnosis?

16 years old patient presenting with Weakness, fatigue, dyspnea, and Splenomegaly, laboratory findings include: Spherocytes with loss of central pallor, ↑ mean corpuscular hemoglobin concentration (MCHC). Jaundice with unconjugated bilirubin,  + osmotic fragility test, which reveals increased spherocyte fragility in hypotonic solution.

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[q] What is the most likely diagnosis?

22 years old African American presenting with Weakness, fatigue, dyspnea, with prominent facial bones that looks like chipmunk facies and skull x-rays show ‘crewcut’ appearance + he has multiple painful foci, hematuria + ultrasound shows Shrunken, fibrotic spleen + Laboratory findings: HB: 9.2, MCV: 85 + Blood smear is shown below + Hb electrophoresis: 90% HbS, 8% HbF, 2% HbA2 (no HbA1).

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[f]IFNpY2tsZSBjZWxsIGFuZW1pYS4gQXV0b3NvbWFsIHJlY2Vzc2l2ZSBtdXRhdGlvbiBpbiDOsiBjaGFpbiBvZiBoZW1vZ2xvYmluOyBhIHNpbmdsZSBhbWlubyBhY2lkIGNoYW5nZSByZXBsYWNlcyBub3JtYWwgZ2x1dGFtaWMgYWNpZCAoaHlkcm9waGlsaWMpIHdpdGggdmFsaW5lIChoeWRyb3Bob2JpYyku

[q] What is the most likely diagnosis?

35 years old patient presenting with Weakness, fatigue, dyspnea, Hemoglobinuria, Hemosiderinuria, with Decreased serum haptoglobin. Symptoms often occurs episodically, often at night during sleep. CBC shows Pancytopenia. Patient has a previous history of ischemic stroke 2 years ago.

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBhcm94eXNtYWwgbm9jdHVybmFsIGhlbW9nbG9iaW51cmlhLiBBY3F1aXJlZCBkZWZlY3QgaW4gbXllbG9pZCBzdGVtIGNlbGxzIHJlc3VsdGluZyBpbiBhYnNlbnQgZ2x5Y29zeWwgcGhvc3BoYXRpZHlsIGlub3NpdG9sIChHUEkpOyBhIGdseWNvbGlwaWQgbmVjZXNzYXJ5IGZvciB0aGUgYXR0YWNobWVudCBvZiBzZXZlcmFsIGNlbGwtc3VyZmFjZSBwcm90ZWlucywgaW5jbHVkaW5nIENENTUgKGRlY2F5LWFjY2VsZXJhdGluZyBmYWN0b3IpIGFuZCBDRDU5IChNQUMgaW5oaWJpdG9yeSBwcm90ZWluKS4=

[Qq]Suspect PNH in patients with hemolytic anemia, a hypercoagulable state, and pancytopenia.

Complications include iron deficiency anemia (due to chronic loss of hemoglobin in the urine) and acute myeloid leukemia (AML), which develops in 10% of patients.

[q] What is the most likely diagnosis?

African American male presenting with hemoglobinuria and back pain hours after taking sulfa for urinary tract infection + Peripheral blood smear shows Heinz bodies and Bite cells.

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[f]IEdsdWNvc2UgNiBwaG9zcGhhdGUgZGVoeWRyb2dlbmFzZSBkZWZpY2llbmN5LiAmIzgyMTE7IOKGkyBHNlBEICYjODIxMTsmZ3Q7IOKGkyBOQURQSCAmIzgyMTE7Jmd0OyDihpMgcmVkdWNlZCBnbHV0YXRoaW9uZSAmIzgyMTE7Jmd0OyBveGlkYXRpdmUgaW5qdXJ5IGJ5IEgyTzIgJiM4MjEyOy0mZ3Q7IGludHJhdmFzY3VsYXIgaGVtb2x5c2lzLg==[Qq]

[q] What is the most likely diagnosis?

30 years old female with history of SLE presenting with normocytic anemia + positive direct coombs test?

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[f]IEltbXVub2hlbW9seXRpYyBhbmVtaWEgKElnRy1tZWRpYXRlZCBkaXNlYXNlKS4=

[q] What is the most likely diagnosis?

60 years old patient with long history of  Aortic stenosis presenting with mild microcytic anemia + Peripheral blood smear shows Schistocytes.

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[f]IE1hY3JvYW5naW9wYXRoaWMgaGVtb2x5dGljIGFuZW1pYS4=[Qq]

[x][restart]

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