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[h] Hematology & Oncology System Flashcards

[i] Master this session in just 5 minutes.

[q] What is the most likely diagnosis?

40 years old female with long history of rheumatoid arthritis presenting with Weakness, fatigue, dyspnea, pale conjunctiva and skin + laboratory findings include: HB: 8.5, MCV: 83, low corrected reticulocyte count, ↑ ferritin, ↓ TIBC, ↓ serum iron, and ↓ % saturation,↑ Free erythrocyte protoporphyrin (FEP).

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[f]IEFuZW1pYSBvZiBjaHJvbmljIGRpc2Vhc2UuIENocm9uaWMgZGlzZWFzZSByZXN1bHRzIGluIHByb2R1Y3Rpb24gb2YgYWN1dGUgcGhhc2UgcmVhY3RhbnRzIGZyb20gdGhlIGxpdmVyLCBpbmNsdWRpbmcgaGVwY2lkaW4u

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[q] What is the most likely diagnosis?

43 years old patient presenting with fatigue, malaise, pallor, purpura, mucosal bleeding, petechiae, increases susceptibility to infections + laboratory findings include: pancytopenia (anemia, thrombocytopenia, and leukopenia) with low reticulocyte count, ↑ EPO + Bone marrow aspiration is usually “dry” and histopathology shows marrow replacement with fat cells and fibrous stroma.

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[q] …. is a rare form of marrow failure characterized by severe hypoplasia of marrow erythroid elements in the setting of normal granulopoiesis and thrombopoiesis.

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UFJDQSBjYW4gYWxzbyByZXN1bHQgZnJvbSBwYXJ2b3ZpcnVzIEIxOSBpbmZlY3Rpb24uIFRoaXMgdmlydXMgcHJlZmVyZW50aWFsbHkgYXR0YWNrcyBhbmQgZGVzdHJveXMgcHJvZXJ5dGhyb2JsYXN0cy4gUmVjZW50IHBhcnZvdmlydXMgaW5mZWN0aW9uIGNhbiBiZSBjb25maXJtZWQgdmlhIHRoZSBkZXRlY3Rpb24gb2YgYW50aS1CMTkgSWdNIGFudGlib2RpZXMgaW4gdGhlIHNlcnVtLg==

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[Qq]

When a thymoma is present, removal can occasionally cure PRCA. Thus, all patients with PRCA should undergo a chest CT scan.

[q] What is the most likely diagnosis?

22 years old patient with long history of alcohol use presenting with abdominal pain, Polyneuropathy, Psychological disturbances, Port wine-stained urine.

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[f]IEFjdXRlIGludGVybWl0dGVudCBwb3JwaHlyaWEu

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[Qq]

Acculamted substrate: Porphobilinogen, ALA.

[q] ALA synthase is upregulated by ….. and downregulated by …..

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[q] What is the most likely diagnosis?

32 years old patient with history of hepatitis C presenting with Blistering cutaneous photosensitivity and hyperpigmentation Exacerbated with alcohol consumption.

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[q] What is the most likely diagnosis?

3 years old child presenting with Nausea, vomiting, gastric bleeding, lethargy after taking his mother’s tablet that looks like candy.

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[f]IEFjdXRlIGlyb24gcG9pc29uaW5nLg==

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VHJlYXRtZW50IGlzIENoZWxhdGlvbiAoSVYgZGVmZXJveGFtaW5lLCBvcmFsIGRlZmVyYXNpcm94KSBhbmQgZ2FzdHJpYyBsYXZhZ2Uu[Qq]

[q] What is the most likely diagnosis?

8 years old child presenting with acute presentation of anemia (fatigue), thrombocytopenia (bleeding), or neutropenia (infection) + Bone marrow shows > 20% blasts in the bone marrow, blasts cells show positive nuclear staining for TdT (DNA polymerase) that express CD10, CD19, and CD20 + cytogenic analysis shows  t(12;21).

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[q] What is the most likely diagnosis?

18 years old patient presenting with acute presentation of anemia (fatigue), thrombocytopenia (bleeding), or neutropenia (infection) + Bone marrow shows > 20% blasts in the bone marrow, blasts cells show positive nuclear staining for TdT (DNA polymerase) that express markers ranging from CD2 to CD8 (CD3, CD4, CD7) + symptoms of facial plethora, facial edema and swelling, dysphagia, dyspnea and stridor.

 

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[f]IFByZWN1cnNvciBULSBBY3V0ZSBseW1waG9ibGFzdGljIGxldWtlbWlhLiBVc3VhbGx5IHByZXNlbnRzIGluIHRlZW5hZ2VycyBhcyBhIG1lZGlhc3RpbmFsICh0aHltaWMpIG1hc3MgKGNhbGxlZCBhY3V0ZSBseW1waG9ibGFzdGljIGx5bXBob21hIGJlY2F1c2UgdGhlIG1hbGlnbmFudCBjZWxscyBmb3JtIGEgbWFzcykgdGhhdCBjYW4gY29tcHJlc3MgdGhlIGdyZWF0IHZlc3NlbHMsIGNhdXNpbmcgc3VwZXJpb3IgdmVuYSBjYXZhIHN5bmRyb21lLiBJdCBjYW4gYWxzbyBjb21wcmVzcyB0aGUgZXNvcGhhZ3VzIGNhdXNpbmcgZHlzcGhhZ2lhLCB3aGlsZSBjb21wcmVzc2lvbiBvZiB0aGUgdHJhY2hlYSBtYXkgbGVhZCB0byBkeXNwbmVhIGFuZCBzdHJpZG9yLg==

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[q] What is the most likely diagnosis?

60 years old patient presenting with acute presentation of anemia (fatigue), thrombocytopenia (bleeding), or neutropenia (infection) + Bone marrow shows > 20% blasts in the bone marrow, blasts cells show positive cytoplasmic staining for myeloperoxidase (MPO) with Crystal aggregates + cytogenic analysis shows  t (15;17).

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[f]IEFjdXRlIHByb215ZWxvY3l0aWMgbGV1a2VtaWEgKEFQTCku

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JiM4MjExOyBDaGFyYWN0ZXJpemVkIGJ5IHQgKDE1OzE3KSwgd2hpY2ggaW52b2x2ZXMgdHJhbnNsb2NhdGlvbiBvZiB0aGUgcmV0aW5vaWMgYWNpZCByZWNlcHRvciAoUkFSKSBvbiBjaHJvbW9zb21lIDE3IHRvIGNocm9tb3NvbWUgMTU7IFJBUiBkaXNydXB0aW9uIGJsb2NrcyBtYXR1cmF0aW9uIGFuZCBwcm9teWVsb2N5dGVzIChibGFzdHMpIGFjY3VtdWxhdGUu

[Qq]

– Abnormal promyelocytes contain numerous primary granules (Auer rods) that increase the risk for DIC.

– Treatment is with all-trans-retinoic acid (ATRA, a vitamin A derivative), which binds the altered receptor and causes the blasts to mature and eventually die.

[q] What is the most likely diagnosis?

8 years old child presenting with acute presentation of anemia (fatigue), thrombocytopenia (bleeding), or neutropenia (infection) + Bone marrow shows < 20% blasts in the bone marrow.

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[f]IE15ZWxvZHlzcGxhc3RpYyBzeW5kcm9tZS4=

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TW9zdCBwYXRpZW50cyBkaWUgZnJvbSBpbmZlY3Rpb24gb3IgYmxlZWRpbmcsIHRob3VnaCBzb21lIHByb2dyZXNzIHRvIGFjdXRlIGxldWtlbWlhLg==[Qq]

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