Start fighting for USMLE success today with the most high-yield questions!

9- Musculoskeletal System (3 Hours & 37 minutes)

[vdo id=’1d6b0ea34e3f4050b93d19bfb5a0f415′]

 

   Content of this Session
  • Bone tumors
  • Degenerative joint disease (osteoarthritis)
  • Rheumatoid arthritis
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Inflammatory bowel disease
  • Reactive arthritis
  • Gout
  • Pseudogout
  • Septic arthritis

 

 

[qwiz style=”width: auto !important; min-height: auto !important; border-width: 4px !important; border-color: #0099cc !important; ” align=”center”]

[h] Musculoskeletal System Flashcards

[i] Master this session in just 5 minutes.

[q] “What is the most likely diagnosis?

20 years old male patient presenting with bone pain (worse at night) that resolves with aspirin + xray shows radiolucent core surrounded by a rim of reactive bone in the cortex of the femur (< 2 cm)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEIuIE9zdGVvaWQgb3N0b21hLg==[Qq]

[q] “What is the most likely diagnosis?

20 years old male patient presenting with back pain that doesn’t resolves with aspirin + xray shows bone mass >2 cm in the vertebrae?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IMKgIE9zdGVvYmxhc3RvbWEu[Qq]

[q] “What is the most likely diagnosis?

20 years old male patient presenting with bony mass that appear as lateral projection in the metaphysis of the long bone formed of bone with an overlying cartilage cap?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9zdGVvY2hvbmRyb21hLg==

Cg==

[Qq]

[q] “What is the most likely diagnosis?

20 years old male patient presenting with bony mass that appear as Soap-bubble’ appearance on x-ray in the epiphysis of the long bone + biopsy shows neoplastic mononuclear cells that express RANKL and reactive multinucleated giant cells?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEdpYW50IGNlbGwgdHVtb3IgKE9zdGVvY2xhc3RvbWEpLg==

Cg==

[Qq]

[q] “What is the most likely diagnosis?

20 years old male patient presenting with pathologic fracture and bone pain with swelling + x-ray shows bony mass in the metaphysis of the lone bone, elevation of periosteum forming angle with the bone + periosteal reaction in the form of sunburst appearance + Biopsy reveals pleomorphic cells that produce osteoid?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9zdGVvc2FyY29tYSAob3N0ZW9nZW5pYyBzYXJjb21hKS4=

Cg==

[Qq]

[q] “What is the most likely diagnosis?

20 years old male patient presenting with bony mass in the diaphysis of the femur, periosteal reaction in the form of onion skin appearance, biopsy shows poorly differentiated small round blue cells that resembles lymphocytes with t (11,22)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEV3aW5nIHNhcmNvbWEu

Cg==

[Qq]

[q] “What is the most likely diagnosis?

55 years old female presenting with joint stiffness in the morning that lasts <30 minutes in the knee joint that worsens by the end of the day, improving with rest + x-ray shows loss of articular cartilage with bone-space narrowing + subchondral sclerosis and cysts with osteophyte formation + systemic symptoms?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IERlZ2VuZXJhdGl2ZSBqb2ludCBkaXNlYXNlIChvc3Rlb2FydGhyaXRpcykuIE1lY2hhbmljYWwgJiM4MjE2O3dlYXIgYW5kIHRlYXImIzgyMTc7IGRlc3Ryb3lzIGFydGljdWxhciBjYXJ0aWxhZ2UgKOKAnGRlZ2VuZXJhdGl2ZSBqb2ludCBkaXNlYXNl4oCdKS4=

Cg==

[Qq]

[q] “What is the most likely diagnosis?

55 years old female presenting with joint stiffness in the morning that lasts > 1 hour, improving with use in the knee joint, + x-ray shows loss of articular cartilage and osteopenia + positive blood tests (RF + Anti CCP antibodies)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFJoZXVtYXRvaWQgYXJ0aHJpdGlzLiBBdXRvaW1tdW5lIGluZmxhbW1hdG9yeSBjeXRva2luZXMgYW5kIGNlbGxzIGluZHVjZSBwYW5udXMgKHByb2xpZmVyYXRpdmUgZ3JhbnVsYXRpb24gdGlzc3VlKSBmb3JtYXRpb24sIHdoaWNoIGVyb2RlcyBhcnRpY3VsYXIgY2FydGlsYWdlIGFuZCBib25lLg==

Cg==

U21hbGwgam9pbnRzIG1vcmUgY29tbW9ubHkgYWZmZWN0ZWQ6IE1DUCwgUElQLCB3cmlzdDsgRElQIGlzIHVzdWFsbHkgc3BhcmVkLCB1bmxpa2Ugb3N0ZW9hcnRocml0aXMu[Qq]

[q] joint deformities associated with Rheumatoid arthritis are ….?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]

Cg==

MS4gU3ltbWV0cmljIGludm9sdmVtZW50IG9mIFBJUCBqb2ludHMgb2YgdGhlIGZpbmdlcnMg4oaSIHN3YW4tbmVjayAoaHlwZXJleHRlbnNpb24gYXQgdGhlIHByb3hpbWFsIGludGVycGhhbGFuZ2VhbCBqb2ludHMgd2l0aCBmbGV4aW9uIGF0IHRoZSBkaXN0YWwgaW50ZXJwaGFsYW5nZWFsIGpvaW50cykgYW5kIGJvdXRvbm5pZXJlIGRlZm9ybWl0eS4=

Cg==

Mi4gV3Jpc3RzIOKGkiB1bG5hciBkZXZpYXRpb24u

[Qq]

3. Cervical spine subluxation is also common and may lead to severe disability due to pain and spinal instability, and potentially to radiculopathy and cord compression.

[q] “What is the most likely diagnosis?

Patient with history of psoriasis presenting with low back pain with inflamed digits that looks like sausage + x-ray shows DIP joint deformity that looks like pencil in cup?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBzb3JpYXRpYyBhcnRocml0aXMuIFN0cm9uZyBhc3NvY2lhdGlvbiB3aXRoIEhMQS1CMjcgKE1IQyBjbGFzcyBJIHNlcm90eXBlKS4=[Qq]

[q] “What is the most likely diagnosis?

35 years old male presenting with low back and buttock pain with morning stiffness lasting > 30 minutes with decrease to spinal motility + inflammation and tenderness at the site of patellar and Achilles tendon insertion + x ray show fusion of the vertebrae and sacroiliitis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==

Cg==

[Qq]

[f]IEFua3lsb3Npbmcgc3BvbmR5bGl0aXMuIFN0cm9uZyBhc3NvY2lhdGlvbiB3aXRoIEhMQS1CMjcgKE1IQyBjbGFzcyBJIHNlcm90eXBlKS4=

Cg==

UHVsbW9uYXJ5IGludm9sdmVtZW50IGNhbiBvY2N1ciBkdWUgdG8gZW50aGVzb3BhdGhpZXMgb2YgdGhlIGNvc3RvdmVydGVicmFsIGFuZCBjb3N0b3N0ZXJuYWwganVuY3Rpb25zLiBQYWluIGNhbiBsaW1pdCBjaGVzdCB3YWxsIGV4cGFuc2lvbiBsZWFkaW5nIHRvIA==aHlwb3ZlbnRpbGF0aW9uLiBDaGVzdCBleHBhbnNpb24gc2hvdWxkIGJlIG1vbml0b3JlZCByZWd1bGFybHkgaW4gcGF0aWVudHMgd2l0aCBhbmt5bG9zaW5nIHNwb25keWxpdGlzLg==

[Qq]

Anterior uveitis develops in 20-30% of patients with ankylosing spondylitis and presents with pain, blurred vision, photophobia and conjunctival erythema.

[q] “What is the most likely diagnosis?

Patient presenting with asymmetric oligoarthritis 2 weeks after campylobacter infection + urethritis + conjunctivitis + skin lesion that looks like pustular psoriasis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFJlYWN0aXZlIGFydGhyaXRpcy4gU3Ryb25nIGFzc29jaWF0aW9uIHdpdGggSExBLUIyNyAoTUhDIGNsYXNzIEkgc2Vyb3R5cGUpLg==[Qq]

[q] “What is the most likely diagnosis?

40 years old male presenting with multiple episodes of painful first metatarsophalangeal joint (MTP) joint of big toe after a large meal or alcohol consumption + arthrocentesis is done and showed needle shaped and ⊝ birefringent under polarized light (when the crystals are aligned parallel to the slow ray of the compensator, they appear yellow, and when aligned perpendicular, they are blue)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEdvdXQu

Cg==

QWN1dGUgaW5mbGFtbWF0b3J5IG1vbm9hcnRocml0aXMgY2F1c2VkIGJ5IHByZWNpcGl0YXRpb24gb2YgbW9ub3NvZGl1bSB1cmF0ZSBjcnlzdGFscyBpbiBqb2ludHMg4oaSIHVwdGFrZSBvZiB1cmF0ZSBjcnlzdGFscyBieSBuZXV0cm9waGlscyBsZWFkcyB0byBmcmVlIHJhZGljYWwgcmVsZWFzZSwgY3l0b2tpbmUgcHJvZHVjdGlvbiB0cmlnZ2VyaW5nIGFuIGFjdXRlIGluZmxhbW1hdG9yeSByZWFjdGlvbi4=[Qq]

[q] “What is the most likely diagnosis?

65 years old male presenting with hot, tender, swollen knee + arthrocentesis is done and showed the presence of rhomboid-shaped crystals positively birefringent under polarized light (blue when aligned parallel to the slow ray of the compensator and yellow when aligned perpendicularly) + x-ray shows – Chondrocalcinosis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBzZXVkb2dvdXQu

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Patient presenting with hot, tender, swollen knee + arthrocentesis is done and showed purulent or cloudy synovial fluid, absent crystals and high synovial fluid leukocyte count (>100.000/mm3)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNlcHRpYyBhcnRocml0aXMu

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Child presenting with bone pain at the lower leg with normal mobility of the joints + fever + leukocytosis + x-ray shows lytic focus in the metaphysis of the long bones?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9zdGVvbXllbGl0aXMu

Cg==

U3RhcGh5bG9jb2NjdXMgYXVyZXVzOiBtb3N0IGNvbW1vbiBjYXVzZSAoOTAlIG9mIGNhc2VzKS4=

Cg==

SW4gY2hpbGRyZW4sIEl0IHVzdWFsbHkgYWZmZWN0cyB0aGUg[Qq]metaphysis of long bones.

[q] “What is the most likely diagnosis?

Young age male presenting with bone pain (worse at night) that resolves with aspirin + x-ray shows bony mass < 2 cm that appears as radiolucent core surrounded by a rim of reactive bone in the cortical bone?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9zdGVvaWQgb3N0b21hLg==

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Young age male presenting with bone pain that doesn’t resolves with aspirin + x-ray shows bony mass > 2 cm in the vertebrae?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9zdGVvYmxhc3RvbWEu

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Young age male presenting with bone mass + x-ray shows lateral projection of the growth plate (metaphysis) + biopsy shows bone mass surrounded with cartilaginous cap?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9zdGVvY2hvbmRyb21hLg==

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Young age male presenting with bone mass + x-ray shows soap-bubble’ appearance in the epiphysis of the tibia + bone biopsy shows neoplastic mononuclear cells that express RANKL and reactive multinucleated giant ?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEdpYW50IGNlbGwgdHVtb3IgKE9zdGVvY2xhc3RvbWEp

Cg==

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Young age male presenting with multiple pathologic bone fracture, bone pain and swelling + x-ray shows sunburst” periosteal reaction and Codman triangle in the metaphysis of the femur + bone Biopsy reveals pleomorphic cells that produce osteoid?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9zdGVvc2FyY29tYSAob3N0ZW9nZW5pYyBzYXJjb21hKS4=

Cg==

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Young age male presenting with multiple pathologic bone fracture, bone pain and swelling + x-ray shows “Onion skin” periosteal reaction in the diaphysis of the long bone + bone biopsy shows reveals small, round blue cells that resemble lymphocytes with t(22, 11)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEV3aW5nIHNhcmNvbWEu

Cg==

Cg==

[Qq]

[q] “What is the most likely diagnosis?

60 years old obese female presenting with joint stiffness of the knee joint in the morning that worsens by the end of the day, improving with rest + joint findings shows fissuring and flaking of articular cartilage, subchondral sclerosis and cysts,  Osteophyte formation in the DIP and PIP joints of the fingers, Joint space narrowing, Synovial fluid WBC < 2000/mm3?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IERlZ2VuZXJhdGl2ZSBqb2ludCBkaXNlYXNlIChvc3Rlb2FydGhyaXRpcyku

Cg==

Cg==

[Qq]

[q] Osteophyte formation in the DIP is called …… and PIP is called …..?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEhlYmVyZGVuIG5vZGVzLCBCb3VjaGFyZCBub2Rlcy4=

Cg==

[Qq]

[q] “What is the most likely diagnosis?

40 years old female presenting with Pain, swelling, and morning stiffness lasting > 1 hour in the hand with ulnar deviation, improving with use + joint findings include Joint space narrowing, loss of cartilage, Synovial fluid WBC > 2000/mm3 + blood test shows + RF and anti CCP antibody

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFJoZXVtYXRvaWQgYXJ0aHJpdGlzLg==

Cg==

[Qq]

[q] All patients with RA should be screened with a ….. before intubation or anesthesia is performed?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBsYWluIHgtcmF5IGZvciBDMS1DMiBzdWJsdXhhdGlvbg==[Qq]

[q] “What is the most likely diagnosis?

RA + Rheumatoid nodules + pneumoconiosis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENhcGxhbiBzeW5kcm9tZS4=

Cg==

[Qq]

[q] “What is the most likely diagnosis?

RA + Neutropenia + splenomegaly

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEZlbHR5IHN5bmRyb21lLg==[Qq]

[q] The major cause of articular cartilage damage in rheumatoid arthritis is ….., but in osteoarthritis the major cause is ……?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEluZmxhbW1hdG9yeSBwYW5udXMgZm9ybWF0aW9uLCB3ZWFyIGFuZCB0ZWFyIG1lY2hhbmljYWwgZGFtYWdlLg==[Qq]

[q] “What is the most likely diagnosis?

35 years old female with salmon colored patches covered with slivery scales presenting with back pain and inflamed digits that looks like sausage + x-ray shows pencil in cup deformity + blood test shows positive HLA-B27?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBzb3JpYXRpYyBhcnRocml0aXM=

Cg==

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Young age male presenting with with morning stiffness and back, buttock pain with limitations to the spinal mobility + x-ray shows fusion of the lumbar vertebrae and sacroiliitis + blood test shows positive HLA-B27?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEFua3lsb3Npbmcgc3BvbmR5bGl0aXMu

Cg==

Cg==

[Qq]

[q] Enthesopathies of the costovertebral and costosternal junctions can limit chest wall expansion leading to hypoventilation. …… should be monitored regularly in patients with ankylosing spondylitis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IENoZXN0IGV4cGFuc2lvbiBzaG91bGQgYmUgbW9uaXRvcmVkIHJlZ3VsYXJseSBpbiBwYXRpZW50cyB3aXRoIGFua3lsb3Npbmcgc3BvbmR5bGl0aXMu[Qq]

[q] “What is the most likely diagnosis?

Patient with history of psoriasis presenting with low back pain with inflamed digits that looks like sausage + x-ray shows DIP joint deformity that looks like pencil in cup?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBzb3JpYXRpYyBhcnRocml0aXMuIFN0cm9uZyBhc3NvY2lhdGlvbiB3aXRoIEhMQS1CMjcgKE1IQyBjbGFzcyBJIHNlcm90eXBlKS4=[Qq]

[q] “What is the most likely diagnosis?

35 years old male presenting with low back and buttock pain with morning stiffness lasting > 30 minutes with decrease to spinal motility + inflammation and tenderness at the site of patellar and Achilles tendon insertion + x ray show fusion of the vertebrae and sacroiliitis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==

Cg==

[Qq]

[f]IEFua3lsb3Npbmcgc3BvbmR5bGl0aXMuIFN0cm9uZyBhc3NvY2lhdGlvbiB3aXRoIEhMQS1CMjcgKE1IQyBjbGFzcyBJIHNlcm90eXBlKS4=

Cg==

UHVsbW9uYXJ5IGludm9sdmVtZW50IGNhbiBvY2N1ciBkdWUgdG8gZW50aGVzb3BhdGhpZXMgb2YgdGhlIGNvc3RvdmVydGVicmFsIGFuZCBjb3N0b3N0ZXJuYWwganVuY3Rpb25zLiBQYWluIGNhbiBsaW1pdCBjaGVzdCB3YWxsIGV4cGFuc2lvbiBsZWFkaW5nIHRvIA==aHlwb3ZlbnRpbGF0aW9uLiBDaGVzdCBleHBhbnNpb24gc2hvdWxkIGJlIG1vbml0b3JlZCByZWd1bGFybHkgaW4gcGF0aWVudHMgd2l0aCBhbmt5bG9zaW5nIHNwb25keWxpdGlzLg==

[Qq]

Anterior uveitis develops in 20-30% of patients with ankylosing spondylitis and presents with pain, blurred vision, photophobia and conjunctival erythema.

[q] “What is the most likely diagnosis?

Patient presenting with asymmetric oligoarthritis 2 weeks after campylobacter infection + urethritis + conjunctivitis + skin lesion that looks like pustular psoriasis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFJlYWN0aXZlIGFydGhyaXRpcy4gU3Ryb25nIGFzc29jaWF0aW9uIHdpdGggSExBLUIyNyAoTUhDIGNsYXNzIEkgc2Vyb3R5cGUpLg==[Qq]

[q] “What is the most likely diagnosis?

40 years old male presenting with multiple episodes of painful first metatarsophalangeal joint (MTP) joint of big toe after a large meal or alcohol consumption + arthrocentesis is done and showed needle shaped and ⊝ birefringent under polarized light (when the crystals are aligned parallel to the slow ray of the compensator, they appear yellow, and when aligned perpendicular, they are blue)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IEdvdXQu

Cg==

QWN1dGUgaW5mbGFtbWF0b3J5IG1vbm9hcnRocml0aXMgY2F1c2VkIGJ5IHByZWNpcGl0YXRpb24gb2YgbW9ub3NvZGl1bSB1cmF0ZSBjcnlzdGFscyBpbiBqb2ludHMg4oaSIHVwdGFrZSBvZiB1cmF0ZSBjcnlzdGFscyBieSBuZXV0cm9waGlscyBsZWFkcyB0byBmcmVlIHJhZGljYWwgcmVsZWFzZSwgY3l0b2tpbmUgcHJvZHVjdGlvbiB0cmlnZ2VyaW5nIGFuIGFjdXRlIGluZmxhbW1hdG9yeSByZWFjdGlvbi4=[Qq]

[q] “What is the most likely diagnosis?

65 years old male presenting with hot, tender, swollen knee + arthrocentesis is done and showed the presence of rhomboid-shaped crystals positively birefringent under polarized light (blue when aligned parallel to the slow ray of the compensator and yellow when aligned perpendicularly) + x-ray shows – Chondrocalcinosis?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFBzZXVkb2dvdXQu

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Patient presenting with hot, tender, swollen knee + arthrocentesis is done and showed purulent or cloudy synovial fluid, absent crystals and high synovial fluid leukocyte count (>100.000/mm3)?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IFNlcHRpYyBhcnRocml0aXMu

Cg==

[Qq]

[q] “What is the most likely diagnosis?

Child presenting with bone pain at the lower leg with normal mobility of the joints + fever + leukocytosis + x-ray shows lytic focus in the metaphysis of the long bones?

[c]IFNob3cgbWUgdG hlIGFuc3dlcg==[Qq]

[f]IE9zdGVvbXllbGl0aXMu

Cg==

U3RhcGh5bG9jb2NjdXMgYXVyZXVzOiBtb3N0IGNvbW1vbiBjYXVzZSAoOTAlIG9mIGNhc2VzKS4=

Cg==

SW4gY2hpbGRyZW4sIEl0IHVzdWFsbHkgYWZmZWN0cyB0aGUg[Qq]metaphysis of long bones.

[x][restart]

[/qwiz]

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